Human immunodeficiency virus (HIV) and Mycobacterium tuberculosis (Mtb) are pathogens
responsible for millions of new infections each year; together, they cause high morbidity and …

The tumor suppressor p53 plays various functional roles in the cell by regulating multiple
regulatory signals that ensure adequate temporal and spatial responses to cellular stress …

The p53 tumor suppressor protein is involved in regulating a wide variety of stress
responses, from senescence and apoptosis to more recently discovered roles in allowing …

Tumour dependency on specific metabolic signals has been demonstrated and often guided
numerous therapeutic approaches. We identify melanoma addiction to the mitochondrial …

HIV-1 Tat is an intrinsically unfolded protein playing a pivotal role in viral replication by
associating with TAR region of viral LTR. Unfolded proteins are degraded by 20S …

β‐transducin repeat‐containing protein (β‐TrCP), one of the well‐characterized F‐box
proteins, acts as a substrate receptor and constitutes an active SCFβ‐TrCP E3 ligase with a …

Viroporins are virally encoded transmembrane proteins that are essential for viral
pathogenicity and can participate in various stages of the viral life cycle, thereby promoting …

Through the combined action of ubiquitinating and deubiquitinating enzymes, conjugation of
ubiquitin to a target protein acts as a reversible post-translational modification functionally …

Host restriction factors affect different phases of a viral life cycle, contributing to innate
immunity as the first line of defense against viruses, including HIV-1. These restriction factors …

Immune thrombocytopenia (ITP) is a common hematological autoimmune disease, in which
defective mesenchymal stem cells (MSCs) are potentially involved. Our previous study …