Astrocytes are abundant glial cells in the central nervous system (CNS) that perform diverse
functions in health and disease. Astrocyte dysfunction is found in numerous diseases …

Prematurity, especially preterm birth (less than 32 weeks' gestation), is common and
associated with high rates of both survival and neurodevelopmental disability, especially …

Human neuroscience has made remarkable progress in understanding basic aspects of
functional organization; it is a renowned fact that the blood–brain barrier (BBB) impedes the …

Neurodegenerative diseases are characterized by extensive loss of function or death of
brain cells, hampering the life quality of patients. Brain-targeted drug delivery is challenging …

Hyperinflammation triggered by SARS-CoV-2 is a major cause of disease severity, with
activated macrophages implicated in this response. OP-101, a hydroxyl-polyamidoamine …

Organ ischemia with inadequate oxygen supply followed by reperfusion (which initiates a
complex of inflammatory responses and oxidative stress) occurs in different clinical …

Advances in nanotechnology have had profound impacts on therapeutic delivery, leading to
the development of nanomaterials engineered with large carrying capabilities and targeting …

Dendrimers have shown great promise as carriers in drug delivery due to their unique
structures and superior properties. However, the precise control of payload release from a …

Mitochondrial oxidative stress is associated with many neurodegenerative diseases, such as
traumatic brain injury (TBI). Targeted delivery of antioxidants to mitochondria has failed to …

Traumatic brain injury (TBI) is a significant medical problem with limited treatment options
and is one of the main causes of life-long disability. Neuroinflammation orchestrated by …