Ischemia/reperfusion injury following acute myocardial infarction: a critical issue for clinicians and forensic pathologists
M Neri, I Riezzo, N Pascale, C Pomara… - Mediators of …, 2017 - Wiley Online Library
Acute myocardial infarction (AMI) is a leading cause of morbidity and mortality. Reperfusion
strategies are the current standard therapy for AMI. However, they may result in paradoxical …
strategies are the current standard therapy for AMI. However, they may result in paradoxical …
Matrix metalloproteinase-9: Many shades of function in cardiovascular disease
Matrix metalloproteinase (MMP)-9, one of the most widely investigated MMPs, regulates
pathological remodeling processes that involve inflammation and fibrosis in cardiovascular …
pathological remodeling processes that involve inflammation and fibrosis in cardiovascular …
IRF3 and type I interferons fuel a fatal response to myocardial infarction
Abstract Interferon regulatory factor 3 (IRF3) and type I interferons (IFNs) protect against
infections and cancer, but excessive IRF3 activation and type I IFN production cause …
infections and cancer, but excessive IRF3 activation and type I IFN production cause …
Neutrophils orchestrate post-myocardial infarction healing by polarizing macrophages towards a reparative phenotype
M Horckmans, L Ring, J Duchene… - European heart …, 2017 - academic.oup.com
Aims Acute myocardial infarction (MI) is the leading cause of mortality worldwide. Anti-
inflammatory strategies to reduce neutrophil-driven acute post-MI injury have been shown to …
inflammatory strategies to reduce neutrophil-driven acute post-MI injury have been shown to …
[HTML][HTML] Resident cardiac macrophages mediate adaptive myocardial remodeling
NR Wong, J Mohan, BJ Kopecky, S Guo, L Du, J Leid… - Immunity, 2021 - cell.com
Cardiac macrophages represent a heterogeneous cell population with distinct origins,
dynamics, and functions. Recent studies have revealed that CC Chemokine Receptor 2 …
dynamics, and functions. Recent studies have revealed that CC Chemokine Receptor 2 …
Cardiac fibroblasts, fibrosis and extracellular matrix remodeling in heart disease
D Fan, A Takawale, J Lee, Z Kassiri - Fibrogenesis & tissue repair, 2012 - Springer
Fibroblasts comprise the largest cell population in the myocardium. In heart disease, the
number of fibroblasts is increased either by replication of the resident myocardial fibroblasts …
number of fibroblasts is increased either by replication of the resident myocardial fibroblasts …
Matrix metalloproteinases in myocardial infarction and heart failure
Cardiovascular disease is the leading cause of death, accounting for 600,000 deaths each
year in the United States. In addition, heart failure accounts for 37% of health care spending …
year in the United States. In addition, heart failure accounts for 37% of health care spending …
Platelets, inflammation and tissue regeneration
AT Nurden - Thrombosis and haemostasis, 2011 - thieme-connect.com
Blood platelets have long been recognised to bring about primary haemostasis with
deficiencies in platelet production and function manifesting in bleeding while upregulated …
deficiencies in platelet production and function manifesting in bleeding while upregulated …
Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6
Quantitative assays for human DNA and mRNA were used to examine the paradox that
intravenously (iv) infused human multipotent stromal cells (hMSCs) can enhance tissue …
intravenously (iv) infused human multipotent stromal cells (hMSCs) can enhance tissue …
Angiogenesis in cancer and other diseases
Pathological angiogenesis is a hallmark of cancer and various ischaemic and inflammatory
diseases. Concentrated efforts in this area of research are leading to the discovery of a …
diseases. Concentrated efforts in this area of research are leading to the discovery of a …