Cyclin-dependent kinases (CDK/Cyclins) form a family of heterodimeric kinases that play
central roles in regulation of cell cycle progression, transcription and other major biological …

Cancer cells preferentially utilize glycolysis, instead of oxidative phosphorylation, for
metabolism even in the presence of oxygen. This phenomenon of aerobic glycolysis …

Cyclin-dependent kinase 9 (CDK9), a member of the cyclin-dependent protein kinase (CDK)
family, is involved in transcriptional elongation of several target genes. CDK9 is ubiquitously …

Cyclin dependent kinase (CDK) inhibitors have been the topic of intense research for nearly
2 decades due to their widely varied and critical functions within the cell. Recently CDK9 has …

The family of cyclin-dependent kinases (CDKs) has critical functions in cell cycle regulation
and controlling of transcriptional elongation. Moreover, dysregulated CDKs have been …

An uncontrolled cell cycle is an obvious marker of tumor cells. The G1‑S phase is an
important restriction point in the normal cell cycle, but in cancer cells the restriction function …

A series of 1-H-pyrazole-3-carboxamide derivatives have been designed and synthesized
that exhibit excellent FLT3 and CDK inhibition and antiproliferative activities. A structure …

In the early 2000s, the anticancer drug imatinib (Glivec®) appeared on the market, exhibiting
a new mode of action by selective kinase inhibition. Consequently, kinases became a …

Cisplatin, paclitaxel and bortezomib belong to some of the most effective families of
chemotherapy drugs for solid and haematological cancers. Epothilones represent a new …

Cyclin-dependent kinase 2 (CDK2) is a crucial regulator of the eukaryotic cell cycle.
However it is well established that monomeric CDK2 lacks regulatory activity, which needs …