Lung cancer is a major global health problem, as it is the leading cause of cancer-related
deaths worldwide. Major advances in the identification of key mutational alterations have led …

Lung cancer is the most common and fatal malignant tumor in the world. The tumor
microenvironment (TME) is closely related to the occurrence and development of lung …

In the past decades, our knowledge about the relationship between cancer and the immune
system has increased considerably. Recent years' success of cancer immunotherapy …

Lung cancer is a leading cause of cancer-related deaths worldwide. About 10–30% of
patients with non-small cell lung cancer (NSCLC) harbor mutations of the EGFR gene. The …

Background: Tumor associated macrophages (TAMs) have strong plasticity and if
reprogrammed, can clear tumor cells and regulate the adaptive immune system for cancer …

Lung cancer is the deadliest malignancy worldwide. An inflammatory microenvironment is a
key factor contributing to lung tumor progression. Tumor-Associated Macrophages (TAMs) …

Background Accumulating evidence suggests that M2-polarized tumor-associated
macrophages (TAMs) play an important role in cancer progression and metastasis, making …

Data from mouse tumor models suggest that tumor-associated monocyte/macrophage
lineage cells (MMLCs) dampen antitumor immune responses. However, given the …

Tissue regeneration is a multi-step process mediated by diverse cellular hierarchies and
states that are also implicated in tissue dysfunction and pathogenesis. Here we leveraged …

Lung diseases carry a significant burden of morbidity and mortality worldwide. The advent of
digital pathology (DP) and an increase in computational power have led to the development …