Host–transposon interactions: conflict, cooperation, and cooption
Transposable elements (TEs) are mobile DNA sequences that colonize genomes and
threaten genome integrity. As a result, several mechanisms appear to have emerged during …
threaten genome integrity. As a result, several mechanisms appear to have emerged during …
The key role of lysosomal protease cathepsins in viral infections
M Scarcella, D d'Angelo, M Ciampa, S Tafuri… - International journal of …, 2022 - mdpi.com
Cathepsins encompass a family of lysosomal proteases that mediate protein degradation
and turnover. Although mainly localized in the endolysosomal compartment, cathepsins are …
and turnover. Although mainly localized in the endolysosomal compartment, cathepsins are …
Intercellular communication within the virus microenvironment affects the susceptibility of cells to secondary viral infections
Communication between infected cells and cells in the surrounding tissue is a determinant
of viral spread. However, it remains unclear how cells in close or distant proximity to an …
of viral spread. However, it remains unclear how cells in close or distant proximity to an …
Human cytomegalovirus tegument protein pp65 (pUL83) dampens type I interferon production by inactivating the DNA sensor cGAS without affecting STING
The innate immune response plays a pivotal role during human cytomegalovirus (HCMV)
primary infection. Indeed, HCMV infection of primary fibroblasts rapidly triggers strong …
primary infection. Indeed, HCMV infection of primary fibroblasts rapidly triggers strong …
The IGF-1 signaling pathway in viral infections
Insulin-like growth factor-1 (IGF-1) and the IGF-1 receptor (IGF-1R) belong to the insulin-like
growth factor family, and IGF-1 activates intracellular signaling pathways by binding …
growth factor family, and IGF-1 activates intracellular signaling pathways by binding …
Recent advancement in nanotechnology-based drug delivery system against viral infections
In the last few decades, the exponential rise in the incidence of viral infections sets a global
health emergency across the world. The biomimetic architecture, the ability to hijack host …
health emergency across the world. The biomimetic architecture, the ability to hijack host …
Mono-ADP-ribosylation by PARP10 inhibits Chikungunya virus nsP2 proteolytic activity and viral replication
S Krieg, F Pott, L Potthoff, M Verheirstraeten… - Cellular and Molecular …, 2023 - Springer
Replication of viruses requires interaction with host cell factors and repression of innate
immunity. Recent findings suggest that a subset of intracellular mono-ADP-ribosylating …
immunity. Recent findings suggest that a subset of intracellular mono-ADP-ribosylating …
How viruses contribute to the pathogenesis of hemophagocytic lymphohistiocytosis
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening, hyperinflammatory
syndrome, characterized by the uncontrolled activation of macrophages and T cells, eliciting …
syndrome, characterized by the uncontrolled activation of macrophages and T cells, eliciting …
Comparative proteomics identifies Schlafen 5 (SLFN5) as a herpes simplex virus restriction factor that suppresses viral transcription
Intrinsic antiviral host factors confer cellular defence by limiting virus replication and are
often counteracted by viral countermeasures. We reasoned that host factors that inhibit viral …
often counteracted by viral countermeasures. We reasoned that host factors that inhibit viral …
Perspective of HLA-G induced immunosuppression in SARS-CoV-2 infection
A Lin, WH Yan - Frontiers in immunology, 2021 - frontiersin.org
COVID-19, the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2), has threatened public health worldwide. Host antiviral immune responses are …
CoV-2), has threatened public health worldwide. Host antiviral immune responses are …