Neonatal sepsis remains one of the key challenges of neonatal medicine, and together with
preterm birth, causes almost 50% of all deaths globally for children younger than 5 years …

Antibiotic use is a risk factor for development of inflammatory bowel diseases (IBDs). IBDs
are characterized by a damaged mucus layer, which does not separate the intestinal …

Neonatal sepsis is a clinical syndrome mainly associated with a bacterial infection leading to
severe clinical manifestations that could be associated with fatal sequalae. According to the …

Importance Antibiotic treatment saves lives in newborns with early-onset sepsis (EOS), but
unwarranted antibiotic use is associated with resistant bacteria and adverse outcomes later …

Background As the survival of preterm infants has increased, the management of long-term
complications, especially neurodevelopmental impairment, becomes increasingly important …

Objectives Wide variations in antibiotic use in very preterm infants have been reported
across centres despite similar rates of infection. We describe 10 year trends in use of …

Background Early-life antibiotic exposure is disproportionately high compared to the burden
of culture-proven early-onset sepsis (CP-EOS). We assessed the contribution of culture …

Understanding the interrelationship between the gut microbiota and host physiology,
although still in its relative infancy, has taken important steps forward over the past decade …

Bacterial infection hampers wound repair by impeding the healing process. Concurrently,
inflammation at the wound site triggers the production of reactive oxygen species (ROS) …

Methicillin-resistant Staphylococcus aureus (MRSA) acquires high-level resistance against β-
lactam antibiotics by expressing penicillin-binding protein 2a (PBP2a). PBP2a is a cell wall …