Macrophages, which are key cellular components of the liver, have emerged as essential
players in the maintenance of hepatic homeostasis and in injury and repair processes in …

Thrombosis with associated inflammation (thromboinflammation) occurs commonly in a
broad range of human disorders. It is well recognized clinically in the context of superficial …

Sepsis is a potentially fatal condition caused by dysregulation of the body's immune
response to an infection. Sepsis-induced liver injury is considered a strong independent …

Platelets are the primary cellular mediators of hemostasis and this function firmly acquaints
them with a variety of inflammatory processes. For example, platelets can act as circulating …

Beyond their important role in hemostasis, platelets play a crucial role in inflammatory
diseases. This becomes apparent during sepsis, where platelet count and activation …

Platelets prevent blood loss during vascular injury and contribute to thrombus formation in
cardiovascular disease. Beyond these classical roles, platelets are critical for the host …

Platelets are chief cells in hemostasis. Apart from their hemostatic roles, platelets are major
inflammatory effector cells that can influence both innate and adaptive immune responses …

Podoplanin is a small cell-surface mucin-like glycoprotein that plays a crucial role in the
development of the alveoli, heart, and lymphatic vascular system. Emerging evidence …

Thrombosis is a common consequence of infection that is associated with poor patient
outcome. Nevertheless, the mechanisms by which infection-associated thrombosis is …

Patients with cancer have an increased risk of thromboembolism, which is the second
leading cause of death in these patients. Several mechanisms of the prothrombotic state in …