In recent years, an abundance of new molecular structures have been elucidated using cryo-
electron microscopy (cryo-EM), largely due to advances in hardware technology and data …

Deep learning is transforming most areas of science and technology, including electron
microscopy. This review paper offers a practical perspective aimed at developers with …

Cryo-EM maps are valuable sources of information for protein structure modeling. However,
due to the loss of contrast at high frequencies, they generally need to be post-processed to …

We review the growing use of machine learning in electron microscopy (EM) driven in part
by the availability of fast detectors operating at kiloHertz frame rates leading to large data …

Elucidation of both the three-dimensional structure and the dynamics of a protein is essential
to understand its function. Technical breakthroughs in single-particle analysis based on cryo …

The respiratory syncytial virus (RSV) polymerase is a multifunctional RNA-dependent RNA
polymerase composed of the large (L) protein and the phosphoprotein (P). It transcribes the …

Cryo-electron microscopy (cryo-EM) has become a leading technology for determining
protein structures. Recent advances in this field have allowed for atomic resolution …

Cryo-electron microscopy (CryoEM) has become a vital technique in structural biology. It is
an interdisciplinary field that takes advantage of advances in biochemistry, physics, and …

In this article, a method is presented to estimate a new local quality measure for 3D cryoEM
maps that adopts the form of alocal resolution'type of information. The algorithm (DeepRes) …

The respiratory syncytial virus (RSV) RNA polymerase, constituted of a 250 kDa large (L)
protein and tetrameric phosphoprotein (P), catalyzes three distinct enzymatic activities …