Contemporary trauma care comprises advanced pre-hospital care, regionalized trauma
systems, damage control operative techniques, advanced critical care, rehabilitation with …

Traumatic-induced coagulopathy (TIC) is a hemostatic disorder that is associated with
significant bleeding, transfusion requirements, morbidity and mortality. A disorder similar or …

There has been an increased interest in the use of viscoelastic testing to guide blood
product replacement during the acute resuscitation of the injured patient. Currently, no …

BACKGROUND Both tissue plasminogen activator (tPA) in the circulation and urokinase
(uPA) in tissues cleave plasminogen (PLG) to plasmin to promote clot lysis. Tranexamic acid …

Trauma‐induced coagulopathy (TIC) is one of the leading causes of preventable death in
injured patients. Consequently, it is imperative to understand the mechanisms underlying …

Hemorrhage in the setting of severe trauma is a leading cause of death worldwide. The
pathophysiology of hemorrhage and coagulopathy in severe trauma is complex and remains …

Traumatic-induced coagulopathy (TIC) is often associated with significant bleeding,
transfusion requirements, inflammation, morbidity, and mortality. This review considers TIC …

This paper describes the design, fabrication, and testing of a microfluidic sensor for dielectric
spectroscopy of human whole blood during coagulation. The sensor, termed ClotChip …

Metabolic staging after trauma/hemorrhagic shock is a key driver of acidosis and directly
relates to hypothermia and coagulopathy. Metabolic responses to trauma/hemorrhagic …

Uncontrolled bleeding from traumatic injury remains the leading cause of preventable death
with loss of balance between blood clotting (coagulation) and blood clot breakdown …