Repeated, episodic bouts of skeletal muscle contraction undertaken frequently as structured
exercise training are a potent stimulus for physiological adaptation in many organs …

Preservation of aerobic fitness and skeletal muscle strength through exercise training can
ameliorate metabolic dysfunction and prevent chronic disease. These benefits are mediated …

Mammalian skeletal muscle comprises different fiber types, whose identity is first established
during embryonic development by intrinsic myogenic control mechanisms and is later …

Mitochondria are dynamic organelles with multiple functions. They participate in necrotic cell
death and programmed apoptotic, and are crucial for cell metabolism and survival …

Exercise represents a major challenge to whole-body homeostasis provoking widespread
perturbations in numerous cells, tissues, and organs that are caused by or are a response to …

Aging is a general degenerative process related to deterioration of cell functions in the entire
organism. Mitochondria, which play a key role in energy homeostasis and metabolism of …

Mitochondrial dysfunction has been regarded as a hallmark of diabetic cardiomyopathy. In
addition to their canonical metabolic actions, mitochondria influence various other aspects of …

Mechanisms responsible for energy management in the cell and in the whole organism
require a complex network of transcription factors and cofactors. Peroxisome proliferator …

Exercise training benefits many organ systems and offers protection against metabolic
disorders such as obesity and diabetes. Using the recently identified isoform of PGC1-α …

A key metabolic activity of the gut microbiota is the fermentation of non-digestible
carbohydrate, which generates short-chain fatty acids (SCFAs) as the principal end …