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Signaling pathways in Parkinson's disease: molecular mechanisms and therapeutic interventions
X Dong-Chen, C Yong, X Yang, ST Chen-Yu… - Signal transduction and …, 2023 - nature.com
Parkinson's disease (PD) is the second most common neurodegenerative disease
worldwide, and its treatment remains a big challenge. The pathogenesis of PD may be …
worldwide, and its treatment remains a big challenge. The pathogenesis of PD may be …
Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family in physiological and pathophysiological process and diseases
L Qian, Y Zhu, C Deng, Z Liang, J Chen… - Signal transduction and …, 2024 - nature.com
Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family (PGC-1s),
consisting of three members encompassing PGC-1α, PGC-1β, and PGC-1-related …
consisting of three members encompassing PGC-1α, PGC-1β, and PGC-1-related …
Targeting epigenetic and posttranslational modifications regulating ferroptosis for the treatment of diseases
Y Wang, J Hu, S Wu, JS Fleishman, Y Li, Y Xu… - Signal transduction and …, 2023 - nature.com
Ferroptosis, a unique modality of cell death with mechanistic and morphological differences
from other cell death modes, plays a pivotal role in regulating tumorigenesis and offers a …
from other cell death modes, plays a pivotal role in regulating tumorigenesis and offers a …
Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative damage
Y Wei, QQ Miao, Q Zhang, S Mao, M Li, X Xu… - Nature …, 2023 - nature.com
It is generally thought that under basal conditions, neurons produce ATP mainly through
mitochondrial oxidative phosphorylation (OXPHOS), and glycolytic activity only …
mitochondrial oxidative phosphorylation (OXPHOS), and glycolytic activity only …
Pharmacological inhibition of ferroptosis as a therapeutic target for neurodegenerative diseases and strokes
Y Wang, S Wu, Q Li, H Sun, H Wang - Advanced Science, 2023 - Wiley Online Library
Emerging evidence suggests that ferroptosis, a unique regulated cell death modality that is
morphologically and mechanistically different from other forms of cell death, plays a vital role …
morphologically and mechanistically different from other forms of cell death, plays a vital role …
Ferroptosis in Parkinson's disease: molecular mechanisms and therapeutic potential
X Ding, L Gao, Z Han, S Eleuteri, W Shi, Y Shen… - Ageing research …, 2023 - Elsevier
Parkinson's Disease (PD) is characterized by the progressive loss of dopaminergic neurons
in the substantia nigra (SN), leading to motor and non-motor symptoms. While the exact …
in the substantia nigra (SN), leading to motor and non-motor symptoms. While the exact …
Nanozymes for regenerative medicine
X Mou, Q Wu, Z Zhang, Y Liu, J Zhang, C Zhang… - Small …, 2022 - Wiley Online Library
Nanozymes refer to nanomaterials that catalyze enzyme substrates into products under
relevant physiological conditions following enzyme kinetics. Compared to natural enzymes …
relevant physiological conditions following enzyme kinetics. Compared to natural enzymes …
Ferroptosis in hepatocellular carcinoma: mechanisms and targeted therapy
Hepatocellular carcinoma is the most prevalent form of primary liver cancer with a
multifactorial aetiology comprising genetic, environmental, and behavioural factors. Evading …
multifactorial aetiology comprising genetic, environmental, and behavioural factors. Evading …
Quercetin Protects against MPP+/MPTP‐Induced Dopaminergic Neuron Death in Parkinson's Disease by Inhibiting Ferroptosis
ZH Lin, Y Liu, NJ Xue, R Zheng, YQ Yan… - Oxidative Medicine …, 2022 - Wiley Online Library
Ferroptosis, a novel form of regulated cell death, is caused by accumulation of lipid
peroxides and excessive iron deposition. This process has been linked to the death of …
peroxides and excessive iron deposition. This process has been linked to the death of …
Neuromelanin in Parkinson's disease: tyrosine hydroxylase and tyrosinase
Parkinson's disease (PD) is an aging-related disease and the second most common
neurodegenerative disease after Alzheimer's disease. The main symptoms of PD are …
neurodegenerative disease after Alzheimer's disease. The main symptoms of PD are …