The extracellular matrix is a critical component of microbial biofilms, such as dental plaque,
maintaining the spatial arrangement of cells and coordinating cellular functions throughout …

The definition of the heterogeneous group of coagulase-negative staphylococci (CoNS) is
still based on diagnostic procedures that fulfill the clinical need to differentiate between …

Implant infections in orthopaedics, as well as in many other medical fields, are chiefly
caused by staphylococci. The ability of growing within a biofilm enhances the chances of …

Background Progress in contemporary medicine is associated with an increasing number of
immunocompromised individuals. In this vulnerable group, the underlying disease together …

Abstract Abstract| Most Gram-positive bacteria incorporate membrane-or peptidoglycan-
attached carbohydrate-based polymers into their cell envelopes. Such cell-wall …

Recent progress in elucidating the role of the icaADBC-encoded polysaccharide
intercellular adhesin (PIA) or polymeric N-acetyl-glucosamine (PNAG) in staphylococcal …

After the first ancient studies on microbial slime (the name by which the biofilm matrix was
initially indicated), multitudes of studies on the morphology, composition and physiology of …

Staphylococcus aureus and Staphylococcus epidermidis are major human pathogens of
increasing importance due to the dissemination of antibiotic-resistant strains. Evidence …

Device-associated infections involving biofilm remain a persistent clinical problem. We
recently reported that four methicillin-resistant Staphylococcus aureus (MRSA) strains …

Surface-attached colonies of bacteria known as biofilms play a major role in the
pathogenesis of device-related infections. Biofilm colonies are notorious for their resistance …