The regulated transcription of genes determines cell identity and function. Recent structural
studies have elucidated mechanisms that govern the regulation of transcription by RNA …

Cells are compartmentalized by numerous membrane-enclosed organelles and
membraneless compartments to ensure that a wide variety of cellular activities occur in a …

In mammalian cells, two cellular organelles, mitochondria and peroxisomes, share the ability
to degrade fatty acid chains. Although each organelle harbors its own fatty acid β-oxidation …

The Wnt/β-catenin signaling pathway exerts integral roles in embryogenesis and adult
homeostasis. Aberrant activation of the pathway is implicated in growth-associated diseases …

INTRODUCTION The multisubunit Mediator binds RNA polymerase II (Pol II), transduces
regulatory signals from transcription factors to Pol II, facilitates preinitiation complex (PIC) …

Eukaryotic transcription requires the assembly of a multisubunit preinitiation complex (PIC)
composed of RNA polymerase II (Pol II) and the general transcription factors. The coactivator …

Abstract SALT OVERLY SENSITIVE1 (SOS1) is a key component of plant salt tolerance.
However, how SOS1 transcription is dynamically regulated in plant response to different …

Prostate cancer is a hormone-dependent malignancy, whose onset and progression are
closely related to the activity of the androgen receptor (AR) signaling pathway. Due to this …

While Mediator plays a key role in eukaryotic transcription, little is known about its
mechanism of action. This study combines CRISPR-Cas9 genetic screens, degron assays …

Gene transcription by RNA polymerase II (Pol II) is the first step in the expression of the
eukaryotic genome and a focal point for cellular regulation during development …