Investigating the molecular mechanisms of learning and memory using Caenorhabditis elegans
A Rahmani, YL Chew - Journal of Neurochemistry, 2021 - Wiley Online Library
Learning is an essential biological process for survival since it facilitates behavioural
plasticity in response to environmental changes. This process is mediated by a wide variety …
plasticity in response to environmental changes. This process is mediated by a wide variety …
The logic of transgenerational inheritance: timescales of adaptation
T Sengupta, R Kaletsky… - Annual review of cell and …, 2023 - annualreviews.org
Myriad mechanisms have evolved to adapt to changing environments. Environmental stimuli
alter organisms' physiology to create memories of previous environments. Whether these …
alter organisms' physiology to create memories of previous environments. Whether these …
Adult single-nucleus neuronal transcriptomes of insulin signaling mutants reveal regulators of behavior and learning
JS Ange, Y Weng, R Kaletsky, ME Stevenson… - Cell Genomics, 2024 - cell.com
Gene expression in individual neurons can change during development to adulthood and
can have large effects on behavior. Additionally, the insulin/insulin-like signaling (IIS) …
can have large effects on behavior. Additionally, the insulin/insulin-like signaling (IIS) …
Bacterial diet affects the age-dependent decline of associative learning in Caenorhabditis elegans
S Higurashi, S Tsukada, BM Aleogho, JH Park… - Elife, 2023 - elifesciences.org
The causality and mechanism of dietary effects on brain aging are still unclear due to the
long time scales of aging. The nematode Caenorhabditis elegans has contributed to aging …
long time scales of aging. The nematode Caenorhabditis elegans has contributed to aging …
GNAQ mutations drive port wine birthmark-associated Sturge-Weber syndrome: a review of pathobiology, therapies, and current models
Port-wine birthmarks (PWBs) are caused by somatic, mosaic mutations in the G protein
guanine nucleotide binding protein alpha subunit q (GNAQ) and are characterized by the …
guanine nucleotide binding protein alpha subunit q (GNAQ) and are characterized by the …
[HTML][HTML] Neuronal activation of Gαq EGL-30/GNAQ late in life rejuvenates cognition across species
ME Stevenson, G Bieri, R Kaletsky, JS Ange… - Cell reports, 2023 - cell.com
Loss of cognitive function with age is devastating. EGL-30/GNAQ and G αq signaling
pathways are highly conserved between C. elegans and mammals, and murine Gnaq is …
pathways are highly conserved between C. elegans and mammals, and murine Gnaq is …
Atmospheric particulate matter impairs cognition by modulating synaptic function via the nose-to-brain route
C Liang, Y Jiang, T Zhang, Y Ji, Y Zhang, Y Sun… - Science of The Total …, 2023 - Elsevier
Atmospheric particulate matter (PM), a ubiquitous air pollutant, is the leading environmental
risk factor for mortality worldwide. Experimental and epidemiological studies consistently …
risk factor for mortality worldwide. Experimental and epidemiological studies consistently …
Behavioral plasticity
Y Zhang, Y Iino, WR Schafer - Genetics, 2024 - academic.oup.com
Behavioral plasticity allows animals to modulate their behavior based on experience and
environmental conditions. Caenorhabditis elegans exhibits experience-dependent changes …
environmental conditions. Caenorhabditis elegans exhibits experience-dependent changes …
A Tunable and Druggable Mechanism to Delay Forgetting of Olfactory Memories in C. elegans
The poet WB Yeats wrote that “All that is personal soon rots, it must be packed in ice or salt”.
Here we show that in Caenorhabditis elegans nematodes, simple animals with just 302 …
Here we show that in Caenorhabditis elegans nematodes, simple animals with just 302 …
The redundancy and diversity between two novel PKC isotypes that regulate learning in Caenorhabditis elegans
S Hiroki, Y Iino - Proceedings of the National Academy of …, 2022 - National Acad Sciences
The nematode Caenorhabditis elegans learns the concentration of NaCl and moves toward
the previously experienced concentration. In this behavior, the history of NaCl concentration …
the previously experienced concentration. In this behavior, the history of NaCl concentration …