Older adult participation in cancer clinical trials: a systematic review of barriers and interventions

MS Sedrak, RA Freedman, HJ Cohen… - CA: a cancer journal …, 2021‏ - Wiley Online Library
Cancer is a disease of aging and, as the world's population ages, the number of older
persons with cancer is increasing and will make up a growing share of the oncology …

Frailty and cancer: current perspectives on assessment and monitoring

V Goede - Clinical interventions in aging, 2023‏ - Taylor & Francis
Frailty, an age-related condition of increased vulnerability to acute endogenous or
exogenous stressors, is a key barrier to successful treatment of cancer in older people. In …

Practical assessment and management of vulnerabilities in older patients receiving systemic cancer therapy: ASCO guideline update

W Dale, HD Klepin, GR Williams… - Journal of Clinical …, 2023‏ - ascopubs.org
PURPOSE To update the ASCO guideline (2018) on the practical assessment and
management of age-associated vulnerabilities in older patients undergoing systemic cancer …

Geriatric assessment–driven intervention (GAIN) on chemotherapy-related toxic effects in older adults with cancer: a randomized clinical trial

D Li, CL Sun, H Kim, E Soto-Perez-de-Celis… - JAMA …, 2021‏ - jamanetwork.com
Importance Although geriatric assessment–driven intervention improves patient-centered
outcomes, its influence on chemotherapy-related toxic effects remains unknown. Objective …

Practical assessment and management of vulnerabilities in older patients receiving chemotherapy: ASCO guideline for geriatric oncology

SG Mohile, W Dale, MR Somerfield… - Journal of clinical …, 2018‏ - ascopubs.org
Purpose To provide guidance regarding the practical assessment and management of
vulnerabilities in older patients undergoing chemotherapy. Methods An Expert Panel was …

NCCN guidelines® insights: older adult oncology, version 1.2021: featured updates to the NCCN guidelines

E Dotan, LC Walter, IS Browner, K Clifton… - Journal of the National …, 2021‏ - jnccn.org
The NCCN Guidelines for Older Adult Oncology address specific issues related to the
management of cancer in older adults, including screening and comprehensive geriatric …

Functional versus chronological age: geriatric assessments to guide decision making in older patients with cancer

E Soto-Perez-de-Celis, D Li, Y Yuan, YM Lau… - The Lancet …, 2018‏ - thelancet.com
As the worldwide population ages, oncologists are often required to make difficult and
complex decisions regarding the treatment of older people (aged 65 years and older) with …

Communication with older patients with cancer using geriatric assessment: a cluster-randomized clinical trial from the National Cancer Institute Community Oncology …

SG Mohile, RM Epstein, A Hurria, CE Heckler… - JAMA …, 2020‏ - jamanetwork.com
Importance Older patients with cancer and their caregivers worry about the effects of cancer
treatment on aging-related domains (eg, function and cognition). Quality conversations with …

Geriatric assessment and management in cancer

S Rostoft, A O'Donovan, P Soubeyran… - Journal of Clinical …, 2021‏ - ascopubs.org
As the majority of patients with cancer are older than 65 years, most medical, surgical, and
radiation oncologists treat a large number of older adults in their clinical practice. Older …

Measuring aging and identifying aging phenotypes in cancer survivors

JL Guida, TA Ahles, D Belsky, J Campisi… - JNCI: Journal of the …, 2019‏ - academic.oup.com
Observational data have shown that some cancer survivors develop chronic conditions like
frailty, sarcopenia, cardiac dysfunction, and mild cognitive impairment earlier and/or at a …