Stroke is the second leading cause of death with substantial unmet therapeutic needs. To
identify potential stroke therapeutic targets, we estimate the causal effects of 308 plasma …

Following T cell receptor triggering, T cell activation is initiated and amplified by the
assembly at the TCR/CD3 macrocomplex of a multitude of stimulatory enzymes that activate …

T cells are central to the pathogenesis of lupus nephritis (LN), a common complication of
systemic lupus erythematosus (SLE). CD6 and its ligand, activated leukocyte cell adhesion …

La pandemia del nuevo coronavirus ha desafiado la capacidad de respuesta de los
sistemas de salud en la mayorÃa de los paÃses. La estrategia de Cuba ha sido …

CD5 and CD6 are closely related signal-transducing class I scavenger receptors mainly
expressed on lymphocytes. Both receptors are involved in the modulation of the activation …

ABSTRACT Cuba's National Health System has managed to guarantee an effective and
equitable response to COVID-19. Universal and free health coverage, based on primary …

The CD6 glycoprotein is a lymphocyte surface receptor putatively involved in T cell
development and activation. CD6 facilitates adhesion between T cells and antigen …

CD6 is associated with T-cell modulation and is implicated in several autoimmune diseases.
We previously demonstrated that Itolizumab, a CD6 domain 1 (CD6D1) specific humanized …

Background CD6 is one of many cell surface receptors known to regulate signal
transduction upon T cell activation. However, whether CD6 mediates costimulatory or …

Cancer management still requires more potent and safer treatments, of which
immunomodulatory receptors on the lymphocyte surface have started to show promise in …