Aging involves a diverse set of biological changes accumulating over time that leads to
increased risk of morbidity and mortality. Epigenetic clocks are now widely used to quantify …

Identifying and validating molecular targets of interventions that extend the human health
span and lifespan has been difficult, as most clinical biomarkers are not sufficiently …

Background: The incidence and severity of coronavirus disease 2019 (COVID-19) among
HIV-positive persons receiving antiretroviral therapy (ART) have not been characterized in …

Age-associated changes to the mammalian DNA methylome are well documented and
thought to promote diseases of aging, such as cancer. Recent studies have identified …

Background The increasing numbers of people living with HIV (PLHIV) who are receiving
antiretroviral therapy (ART) have near normal life-expectancy, resulting in more people …

Numerous studies have shown that epigenetic age—an individual's degree of aging based
on patterns of DNA methylation—can be computed and is associated with an array of factors …

Background Ageing is one of the principal risk factors for many chronic diseases. However,
there is considerable between-person variation in the rate of ageing and individual …

Aging and psychosocial stress are associated with increased inflammation and disease risk,
but the underlying molecular mechanisms are unclear. Because both aging and stress are …

Background People living with HIV (PLWH), even when viral replication is controlled through
antiretroviral therapy (ART), experience persistent inflammation. This inflammation is partly …

Background Global but predictable changes impact the DNA methylome as we age, acting
as a type of molecular clock. This clock can be hastened by conditions that decrease …