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The synthetic and therapeutic expedition of isoxazole and its analogs
Isoxazole, constituting an important family of five-membered heterocycles with one oxygen
atom and one nitrogen atom at adjacent positions is of immense importance because of its …
atom and one nitrogen atom at adjacent positions is of immense importance because of its …
Protein tyrosine phosphatase 1B (PTP1B) and obesity
H Cho - Vitamins & hormones, 2013 - Elsevier
Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of the leptin and insulin
signaling pathways. The important roles of PTP1B related to obesity and diabetes were …
signaling pathways. The important roles of PTP1B related to obesity and diabetes were …
Synthesis of isoxazoles by hypervalent iodine-induced cycloaddition of nitrile oxides to alkynes
Treatment of oximes with hypervalent iodine leads to substituted isoxazolesvia rapid
formation of nitrile oxides. Reaction with terminal alkynes led to a series of 3, 5-disubstituted …
formation of nitrile oxides. Reaction with terminal alkynes led to a series of 3, 5-disubstituted …
Aldose reductase and protein tyrosine phosphatase 1B inhibitors as a promising therapeutic approach for diabetes mellitus
A Kousaxidis, A Petrou, V Lavrentaki… - European Journal of …, 2020 - Elsevier
Diabetes mellitus is a metabolic disease characterized by high blood glucose levels and
usually associated with several chronic pathologies. Aldose reductase and protein tyrosine …
usually associated with several chronic pathologies. Aldose reductase and protein tyrosine …
Synthesis of chalcones and flavanones using Julia–Kocienski olefination
A new application of Julia–Kocienski olefination for the synthesis of chalcones and
flavanones has been described. 2-(Benzo [d] thiazol-2-ylsulfonyl)-1-phenylethanones have …
flavanones has been described. 2-(Benzo [d] thiazol-2-ylsulfonyl)-1-phenylethanones have …
Epihalohydrins in organic synthesis
Epihalohydrins [2-(halomethyl) oxiranes, 1, 2-epoxy-3-halopropanes](Figure 1) are well-
known versatile synthons and important reagents in the realm of organic synthesis …
known versatile synthons and important reagents in the realm of organic synthesis …
Natural product inspired diversity oriented synthesis of tetrahydroquinoline scaffolds as antitubercular agent
An efficient natural product inspired diversity oriented syn thesis of tetrahydroquinoline
analogues has been developed using the natural carbohydrate derived solid acid catalyst …
analogues has been developed using the natural carbohydrate derived solid acid catalyst …
[HTML][HTML] Synthesis and biological evaluation of amide derivatives of isoxazole-imidazo [2, 1-b] thiazole as anticancer agents
A new series of amide functionality contained isoxazole-imidazo [2, 1-b] thiazole (12a-j)
were synthesized and their structures were characterized by analytical techniques. Further …
were synthesized and their structures were characterized by analytical techniques. Further …
Design and synthesis of 2, 4-disubstituted polyhydroquinolines as prospective antihyperglycemic and lipid modulating agents
A series of 2, 4-disubstituted polyhydroquinoline were synthesized and evaluated for their in
vivo antihyperglycemic as well as antidyslipidemic activities. Several synthesized …
vivo antihyperglycemic as well as antidyslipidemic activities. Several synthesized …
Synthesis of multiply arylated heteroarenes, including bioactive derivatives, via palladium-catalyzed direct C–H arylation of heteroarenes with (pseudo) aryl halides or …
This review with 387 references covers the literature until the end of November 2013 on the
synthesis of multiply arylated heteroarenes via highly selective palladium-catalyzed direct C …
synthesis of multiply arylated heteroarenes via highly selective palladium-catalyzed direct C …