Targeting inflammation in atherosclerosis—from experimental insights to the clinic
Atherosclerosis, a dominant and growing cause of death and disability worldwide, involves
inflammation from its inception to the emergence of complications. Targeting inflammatory …
inflammation from its inception to the emergence of complications. Targeting inflammatory …
How vascular smooth muscle cell phenotype switching contributes to vascular disease
G Cao, X Xuan, J Hu, R Zhang, H **… - Cell Communication and …, 2022 - Springer
Vascular smooth muscle cells (VSMCs) are the most abundant cell in vessels. Earlier
experiments have found that VSMCs possess high plasticity. Vascular injury stimulates …
experiments have found that VSMCs possess high plasticity. Vascular injury stimulates …
Single-cell genomics reveals a novel cell state during smooth muscle cell phenotypic switching and potential therapeutic targets for atherosclerosis in mouse and …
Background: Smooth muscle cells (SMCs) play significant roles in atherosclerosis via
phenotypic switching, a pathological process in which SMC dedifferentiation, migration, and …
phenotypic switching, a pathological process in which SMC dedifferentiation, migration, and …
[PDF][PDF] Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the …
OP-EHEA191011_online 2313..2340 Page 1 Low-density lipoproteins cause atherosclerotic
cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus …
cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus …
Vascular smooth muscle cells in atherosclerosis: time for a re-assessment
Vascular smooth muscle cells (VSMCs) are key participants in both early and late-stage
atherosclerosis. VSMCs invade the early atherosclerotic lesion from the media, expanding …
atherosclerosis. VSMCs invade the early atherosclerotic lesion from the media, expanding …
Vascular smooth muscle cells in atherosclerosis
GL Basatemur, HF Jørgensen, MCH Clarke… - Nature reviews …, 2019 - nature.com
Vascular smooth muscle cells (VSMCs) are a major cell type present at all stages of an
atherosclerotic plaque. According to the 'response to injury'and 'vulnerable …
atherosclerotic plaque. According to the 'response to injury'and 'vulnerable …
Six shades of vascular smooth muscle cells illuminated by KLF4 (Krüppel-Like Factor 4)
C Yap, A Mieremet, CJM de Vries, D Micha… - … , and vascular biology, 2021 - Am Heart Assoc
Multiple layers of vascular smooth muscle cells (vSMCs) are present in blood vessels
forming the media of the vessel wall. vSMCs provide a vessel wall structure, enabling it to …
forming the media of the vessel wall. vSMCs provide a vessel wall structure, enabling it to …
Fate and state of vascular smooth muscle cells in atherosclerosis
Vascular smooth muscle cells (VSMCs) have long been associated with phenotypic
modulation/plasticity or dedifferentiation. Innovative technologies in cell lineage tracing …
modulation/plasticity or dedifferentiation. Innovative technologies in cell lineage tracing …
HDL and reverse cholesterol transport: Basic mechanisms and their roles in vascular health and disease
Cardiovascular disease, with atherosclerosis as the major underlying factor, remains the
leading cause of death worldwide. It is well established that cholesterol ester-enriched foam …
leading cause of death worldwide. It is well established that cholesterol ester-enriched foam …
Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis
In response to various stimuli, vascular smooth muscle cells (SMCs) can de-differentiate,
proliferate and migrate in a process known as phenotypic modulation. However, the …
proliferate and migrate in a process known as phenotypic modulation. However, the …