Understanding genetic variants in context
Over the last three decades, human genetics has gone from dissecting high-penetrance
Mendelian diseases to discovering the vast and complex genetic etiology of common human …
Mendelian diseases to discovering the vast and complex genetic etiology of common human …
Morphological profiling for drug discovery in the era of deep learning
Morphological profiling is a valuable tool in phenotypic drug discovery. The advent of high-
throughput automated imaging has enabled the capturing of a wide range of morphological …
throughput automated imaging has enabled the capturing of a wide range of morphological …
High‐Throughput Formation of Pre‐Vascularized hiPSC‐Derived Hepatobiliary Organoids on a Chip via Nonparenchymal Cell Grafting
H Fan, J Shang, J Li, B Yang, D Zhou… - Advanced …, 2025 - Wiley Online Library
Liver organoids have been increasingly adopted as a critical in vitro model to study liver
development and diseases. However, the pre‐vascularization of liver organoids without …
development and diseases. However, the pre‐vascularization of liver organoids without …
MAGIC matrices: freeform bioprinting materials to support complex and reproducible organoid morphogenesis
Organoids are powerful models of tissue physiology, yet their applications remain limited
due to their relatively simple morphology and high organoid-to-organoid structural …
due to their relatively simple morphology and high organoid-to-organoid structural …
AML patient blasts exhibit polarization defect upon interaction with bone marrow stromal cells
K Saadallah, B Vianay, L Bonnemay, H Pasquer… - bioRxiv, 2024 - biorxiv.org
Hematopoietic stem and progenitor cells (HSPCs) establish specific interactions with bone
marrow stromal cells, leading to their polarization. Given the role of cell polarity in protection …
marrow stromal cells, leading to their polarization. Given the role of cell polarity in protection …