Astrocyte influences on ischemic neuronal death
RA Swanson, W Ying… - Current molecular …, 2004 - ingentaconnect.com
Glutamate excitotoxicity, oxidative stress, and acidosis are primary mediators of neuronal
death during ischemia and reperfusion. Astrocytes influence these processes in several …
death during ischemia and reperfusion. Astrocytes influence these processes in several …
Erythropoietin prevents motor neuron apoptosis and neurologic disability in experimental spinal cord ischemic injury
The cytokine erythropoietin (EPO) possesses potent neuroprotective activity against a
variety of potential brain injuries, including transient ischemia and reperfusion. It is currently …
variety of potential brain injuries, including transient ischemia and reperfusion. It is currently …
Asialoerythropoietin is a nonerythropoietic cytokine with broad neuroprotective activity in vivo
Erythropoietin (EPO) is a tissue-protective cytokine preventing vascular spasm, apoptosis,
and inflammatory responses. Although best known for its role in hematopoietic lineages …
and inflammatory responses. Although best known for its role in hematopoietic lineages …
Erythropoietin is a paracrine mediator of ischemic tolerance in the brain: evidence from an in vitro model
K Ruscher, D Freyer, M Karsch, N Isaev… - Journal of …, 2002 - Soc Neuroscience
In an in vitro model of cerebral ischemia (oxygen glucose deprivation, OGD) we investigated
whether erythropoietin (EPO) plays a critical role in ischemic preconditioning. We found that …
whether erythropoietin (EPO) plays a critical role in ischemic preconditioning. We found that …
Normobaric hypoxia induces tolerance to focal permanent cerebral ischemia in association with an increased expression of hypoxia-inducible factor-1 and its target …
M Bernaudin, AS Nedelec, D Divoux… - Journal of Cerebral …, 2002 - journals.sagepub.com
Tolerance to cerebral ischemia is achieved by preconditioning sublethal stresses, such as
ischemia or hypoxia, paradigms in which the decrease of O2 availability may constitute an …
ischemia or hypoxia, paradigms in which the decrease of O2 availability may constitute an …
Recombinant human erythropoietin counteracts secondary injury and markedly enhances neurological recovery from experimental spinal cord trauma
Erythropoietin (EPO) functions as a tissue-protective cytokine in addition to its crucial
hormonal role in red cell production. In the brain, for example, EPO and its receptor are …
hormonal role in red cell production. In the brain, for example, EPO and its receptor are …
Erythropoietin and the hypoxic brain
HH Marti - Journal of Experimental Biology, 2004 - journals.biologists.com
Normal tissue function in mammals depends on adequate supply of oxygen through blood
vessels. A discrepancy between oxygen supply and consumption (hypoxia) induces a …
vessels. A discrepancy between oxygen supply and consumption (hypoxia) induces a …
Erythropoietin protects against ischaemic acute renal injury
Background. Erythropoietin (EPO) has recently been shown to exert important cytoprotective
and anti-apoptotic effects in experimental brain injury and cisplatin-induced nephrotoxicity …
and anti-apoptotic effects in experimental brain injury and cisplatin-induced nephrotoxicity …
Human recombinant erythropoietin in asphyxia neonatorum: pilot trial
H Elmahdy, AR El-Mashad, H El-Bahrawy… - …, 2010 - publications.aap.org
OBJECTIVE: The goal was to examine biochemical, neurophysiologic, anatomic, and
clinical changes associated with erythropoietin administration to neonates with hypoxic …
clinical changes associated with erythropoietin administration to neonates with hypoxic …
Role of erythropoietin in the brain
CT Noguchi, P Asavaritikrai, R Teng, Y Jia - Critical reviews in oncology …, 2007 - Elsevier
Multi-tissue erythropoietin receptor (EPO-R) expression provides for erythropoietin (EPO)
activity beyond its known regulation of red blood cell production. This review highlights the …
activity beyond its known regulation of red blood cell production. This review highlights the …