Cells encode information in the sequence of biopolymers, such as nucleic acids, proteins,
and glycans. Although glycans are essential to all living organisms, surprisingly little is …

Protein glycosylation and other post-translational modifications are involved in potentially all
aspects of human growth and development. Defective glycosylation has adverse effects on …

Biological conversion of cellulosic biomass to fuels and chemicals offers the high yields to
products vital to economic success and the potential for very low costs. Enzymatic hydrolysis …

Carbohydrates are central players in a number of important biological processes including
cell signaling, cell adhesion, and the regulation of biochemical pathways. Unlike nucleic …

In the biopharmaceutical industry, mammalian cell culture systems, especially Chinese
hamster ovary (CHO) cells, are predominantly used for the production of therapeutic …

Highlights•Glycosylation of antibodies has a range of effects on their binding and effector
functions.•Regulatory agencies require stringent glycan analysis to ensure safety and …

The beginning of the 20 th century marked the dawn of modern medicine with glycan-based
therapies at the forefront. However, glycans quickly became overshadowed as DNA-and …

Glycans have essential roles in biology and the etiology of many diseases. A major hurdle in
studying glycans through functional glycomics is the lack of methods to release glycans from …

The glycome is defined as the glycan repertoire of cells, tissues, and organisms, as found
under specified conditions. The vastly diverse glycome is generated by a nontemplate …

Most proteins are glycosylated. Mass spectrometry methods are used for map**
glycoprotein glycosylation and detailed glycan structural determination. This technology …