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Considering discrepancy when calibrating a mechanistic electrophysiology model
Uncertainty quantification (UQ) is a vital step in using mathematical models and simulations
to take decisions. The field of cardiac simulation has begun to explore and adopt UQ …
to take decisions. The field of cardiac simulation has begun to explore and adopt UQ …
Validation and trustworthiness of multiscale models of cardiac electrophysiology
Computational models of cardiac electrophysiology have a long history in basic science
applications and device design and evaluation, but have significant potential for clinical …
applications and device design and evaluation, but have significant potential for clinical …
Generating Purkinje networks in the human heart
The Purkinje network is an integral part of the excitation system in the human heart. Yet, to
date, there is no in vivo imaging technique to accurately reconstruct its geometry and …
date, there is no in vivo imaging technique to accurately reconstruct its geometry and …
[HTML][HTML] Machine learning in drug development: Characterizing the effect of 30 drugs on the QT interval using Gaussian process regression, sensitivity analysis, and …
Prolonged QT intervals are a major risk factor for ventricular arrhythmias and a leading
cause of sudden cardiac death. Various drugs are known to trigger QT interval prolongation …
cause of sudden cardiac death. Various drugs are known to trigger QT interval prolongation …
Comprehensive uncertainty quantification and sensitivity analysis for cardiac action potential models
Recent efforts to ensure the reliability of computational model-based predictions in
healthcare, such as the ASME V&V40 Standard, emphasize the importance of uncertainty …
healthcare, such as the ASME V&V40 Standard, emphasize the importance of uncertainty …
Enhanced optimization-based method for the generation of patient-specific models of Purkinje networks
Cardiac Purkinje networks are a fundamental part of the conduction system and are known
to initiate a variety of cardiac arrhythmias. However, patient-specific modeling of Purkinje …
to initiate a variety of cardiac arrhythmias. However, patient-specific modeling of Purkinje …
Sex differences in drug-induced arrhythmogenesis
The electrical activity in the heart varies significantly between men and women and results in
a sex-specific response to drugs. Recent evidence suggests that women are more than …
a sex-specific response to drugs. Recent evidence suggests that women are more than …
Predicting drug‐induced arrhythmias by multiscale modeling
Drugs often have undesired side effects. In the heart, they can induce lethal arrhythmias
such as torsades de pointes. The risk evaluation of a new compound is costly and can take a …
such as torsades de pointes. The risk evaluation of a new compound is costly and can take a …
How drugs modulate the performance of the human heart
Many drugs interact with ion channels in the cells of our heart and trigger heart rhythm
disorders with potentially fatal consequences. Computational modeling can provide …
disorders with potentially fatal consequences. Computational modeling can provide …
Microstructural infarct border zone remodeling in the post-infarct swine heart measured by diffusion tensor MRI
Introduction: Computational models of the heart increasingly require detailed microstructural
information to capture the impact of tissue remodeling on cardiac electromechanics in, for …
information to capture the impact of tissue remodeling on cardiac electromechanics in, for …