Third universal definition of myocardial infarction

K Thygesen, JS Alpert, AS Jaffe, ML Simoons… - circulation, 2012 - Am Heart Assoc
Myocardial infarction (MI) can be recognised by clinical features, including
electrocardiographic (ECG) findings, elevated values of biochemical markers (biomarkers) …

Contributions of risk factors and medical care to cardiovascular mortality trends

M Ezzati, Z Obermeyer, I Tzoulaki, BM Mayosi… - Nature Reviews …, 2015 - nature.com
Ischaemic heart disease, stroke, and other cardiovascular diseases (CVDs) lead to 17.5
million deaths worldwide per year. Taking into account population ageing, CVD death rates …

Machine learning for diagnosis of myocardial infarction using cardiac troponin concentrations

D Doudesis, KK Lee, J Boeddinghaus, A Bularga… - Nature Medicine, 2023 - nature.com
Although guidelines recommend fixed cardiac troponin thresholds for the diagnosis of
myocardial infarction, troponin concentrations are influenced by age, sex, comorbidities and …

High-sensitivity troponin in the evaluation of patients with suspected acute coronary syndrome: a stepped-wedge, cluster-randomised controlled trial

ASV Shah, A Anand, FE Strachan, AV Ferry, KK Lee… - The Lancet, 2018 - thelancet.com
Background High-sensitivity cardiac troponin assays permit use of lower thresholds for the
diagnosis of myocardial infarction, but whether this improves clinical outcomes is unknown …

Long-term outcomes in patients with type 2 myocardial infarction and myocardial injury

AR Chapman, ASV Shah, KK Lee, A Anand, O Francis… - Circulation, 2018 - Am Heart Assoc
Background: Type 2 myocardial infarction and myocardial injury are common in clinical
practice, but long-term consequences are uncertain. We aimed to define long-term …

[HTML][HTML] High-sensitivity cardiac troponin I at presentation in patients with suspected acute coronary syndrome: a cohort study

ASV Shah, A Anand, Y Sandoval, KK Lee, SW Smith… - The Lancet, 2015 - thelancet.com
Background Suspected acute coronary syndrome is the commonest reason for emergency
admission to hospital and is a large burden on health-care resources. Strategies to identify …

High sensitivity cardiac troponin and the under-diagnosis of myocardial infarction in women: prospective cohort study

ASV Shah, M Griffiths, KK Lee, DA McAllister… - bmj, 2015 - bmj.com
Objective To evaluate the diagnosis of myocardial infarction using a high sensitivity troponin
I assay and sex specific diagnostic thresholds in men and women with suspected acute …

Use of coronary computed tomographic angiography to guide management of patients with coronary disease

MC Williams, A Hunter, ASV Shah, V Assi… - Journal of the American …, 2016 - jacc.org
Background: In a prospective, multicenter, randomized controlled trial, 4,146 patients were
randomized to receive standard care or standard care plus coronary computed tomography …

Recommendations for Institutions Transitioning to High-Sensitivity Troponin Testing: JACC Scientific Expert Panel

JL Januzzi, SA Mahler, RH Christenson… - Journal of the American …, 2019 - jacc.org
High-sensitivity cardiac troponin (hs-cTn) I or T methods have been in use in certain regions
for years but are now increasingly globally adopted, including in the United States …

Unstable angina: is it time for a requiem?

E Braunwald, DA Morrow - Circulation, 2013 - Am Heart Assoc
Given the importance of cardiac enzyme elevations in the diagnosis of AMI, 8 attention has
been directed to the development of progressively more accurate biomarkers of myocardial …