[HTML][HTML] Brain Hydrophobic Peptides Antagonists of Neurotoxic Amyloid β Peptide Monomers/Oligomers–Protein Interactions

C Gutierrez-Merino - International Journal of Molecular Sciences, 2023 - mdpi.com
Amyloid β (Aβ) oligomers have been linked to Alzheimer's disease (AD) pathogenesis and
are the main neurotoxic forms of Aβ. This review focuses on the following:(i) the Aβ (1–42) …

Raman spectroscopic insights of phase-separated insulin aggregates

S Dolui, A Roy, U Pal, S Kundu, E Pandit… - ACS Physical …, 2024 - ACS Publications
Phase-separated protein accumulation through the formation of several aggregate species
is linked to the pathology of several human disorders and diseases. Our current …

[HTML][HTML] Single-Molecule X-ray Scattering Used to Visualize the Conformation Distribution of Biological Molecules via Single-Object Scattering Sampling

S Lee, H Ki, SJ Lee, H Ihee - International Journal of Molecular Sciences, 2023 - mdpi.com
Biological macromolecules, the fundamental building blocks of life, exhibit dynamic
structures in their natural environment. Traditional structure determination techniques often …

Visualizing Heterogeneous Protein Conformations with Multi-Tilt Nanoparticle-Aided Cryo-Electron Microscopy Sampling

Y Kim, C Kim, SJ Lee, SR Yun, J Choi, SO Kim, Y Yang… - 2024 - academic.oup.com
Studying heterogeneous conformations of small proteins in solution is essential for
understanding their role in biological processes, but achieving this using traditional methods …

Observing Conformational Distribution of Protein using Nanoparticle-Aided Cryo-Electron Microscopy Sampling

Y Kim, C Kim, Y Yang, H Ihee - 13th Asia Pacific Microscopy …, 2025 - scienceopen.com
Characterizing the structural heterogeneity of small proteins is essential for understanding
their biological roles. Conventional methods have been used to investigate the …