Lung cancer LDCT screening and mortality reduction—evidence, pitfalls and future perspectives

M Oudkerk, SY Liu, MA Heuvelmans… - Nature reviews Clinical …, 2021 - nature.com
In the past decade, the introduction of molecularly targeted agents and immune-checkpoint
inhibitors has led to improved survival outcomes for patients with advanced-stage lung …

ERS/ESTS/ESTRO/ESR/ESTI/EFOMP statement on management of incidental findings from low dose CT screening for lung cancer

EL O'Dowd, I Tietzova, E Bartlett… - European journal of …, 2023 - academic.oup.com
Background Screening for lung cancer with low radiation dose computed tomography has a
strong evidence base, is being introduced in several European countries and is …

Data-driven risk stratification and precision management of pulmonary nodules detected on chest computed tomography

C Wang, J Shao, Y He, J Wu, X Liu, L Yang, Y Wei… - Nature Medicine, 2024 - nature.com
The widespread implementation of low-dose computed tomography (LDCT) in lung cancer
screening has led to the increasing detection of pulmonary nodules. However, precisely …

Lung cancer mortality reduction by LDCT screening: UKLS randomised trial results and international meta-analysis

JK Field, D Vulkan, MPA Davies… - The lancet regional …, 2021 - thelancet.com
Background The NLST reported a significant 20% reduction in lung cancer mortality with
three annual low-dose CT (LDCT) screens and the Dutch-Belgian NELSON trial indicates a …

Personalising lung cancer screening: An overview of risk‐stratification opportunities and challenges

K Ten Haaf, CM van der Aalst… - … journal of cancer, 2021 - Wiley Online Library
Randomised clinical trials have shown the efficacy of computed tomography lung cancer
screening, initiating discussions on whether and how to implement population‐based …

Understanding patient barriers and facilitators to uptake of lung screening using low dose computed tomography: a mixed methods sco** review of the current …

D Cavers, M Nelson, J Rostron, KA Robb, LR Brown… - Respiratory …, 2022 - Springer
Background Targeted lung cancer screening is effective in reducing mortality by upwards of
twenty percent. However, screening is not universally available and uptake is variable and …

[HTML][HTML] Hesitancy around low-dose CT screening for lung cancer

JL Dickson, C Horst, A Nair, S Tisi, R Prendecki… - Annals of …, 2022 - Elsevier
Lung cancer is the leading cause of cancer death worldwide. The absence of symptoms in
early-stage (I/II) disease, when curative treatment is possible, results in> 70% of cases being …

Liverpool Lung Project lung cancer risk stratification model: calibration and prospective validation

JK Field, D Vulkan, MPA Davies, SW Duffy, R Gabe - Thorax, 2021 - thorax.bmj.com
Background Early detection of lung cancer saves lives, as demonstrated by the two largest
published low-dose CT screening trials. Optimal implementation depends on our ability to …

[HTML][HTML] Lung cancer screening considerations during respiratory infection outbreaks, epidemics or pandemics: an international association for the study of lung …

RM Huber, M Cavic, A Kerpel-Fronius, L Viola… - Journal of Thoracic …, 2022 - Elsevier
After the results of two large, randomized trials, the global implementation of lung cancer
screening is of utmost importance. However, coronavirus disease 2019 infections occurring …

Develo** a pan-European technical standard for a comprehensive high-quality lung cancer computed tomography screening programme: an ERS technical …

DR Baldwin, EL O'Dowd, I Tietzova… - European …, 2023 - Eur Respiratory Soc
Background Screening for lung cancer with low radiation dose computed tomography
(LDCT) has a strong evidence base. The European Council adopted a recommendation in …