Comprehensive review of uterine fibroids: developmental origin, pathogenesis, and treatment

Q Yang, M Ciebiera, MV Bariani, M Ali… - Endocrine …, 2022 - academic.oup.com
Uterine fibroids are benign monoclonal neoplasms of the myometrium, representing the
most common tumors in women worldwide. To date, no long-term or noninvasive treatment …

A precision environmental health approach to prevention of human disease

A Baccarelli, DC Dolinoy, CL Walker - Nature Communications, 2023 - nature.com
Human health is determined by the interaction of our environment with the genome,
epigenome, and microbiome, which shape the transcriptomic, proteomic, and metabolomic …

Targeting cholesterol metabolism in Cancer: From molecular mechanisms to therapeutic implications

J Lu, S Chen, X Bai, M Liao, Y Qiu, LL Zheng… - Biochemical …, 2023 - Elsevier
Cholesterol is an essential component of cell membranes and helps to maintain their
structure and function. Abnormal cholesterol metabolism has been linked to the …

Role of endocrine-disrupting chemicals in the pathogenesis of non-alcoholic fatty liver disease: a comprehensive review

R Cano, JL Pérez, LA Dávila, Á Ortega… - International journal of …, 2021 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is considered the most common liver disorder,
affecting around 25% of the population worldwide. It is a complex disease spectrum, closely …

Long-term health outcomes of early menarche in women: an umbrella review

JS Lee, YA Lee, CH Shin, DI Suh… - QJM: An International …, 2022 - academic.oup.com
Background There is limited comprehensive evidence on the potential association between
early menarche and subsequent health outcomes. Aim To evaluate the existing evidence for …

Kidney and epigenetic mechanisms of salt-sensitive hypertension

W Kawarazaki, T Fujita - Nature Reviews Nephrology, 2021 - nature.com
Dietary salt intake increases blood pressure (BP) but the salt sensitivity of BP differs
between individuals. The interplay of ageing, genetics and environmental factors, including …

Placenta and fetal brain share a neurodevelopmental disorder DNA methylation profile in a mouse model of prenatal PCB exposure

BI Laufer, K Neier, AE Valenzuela, DH Yasui… - Cell reports, 2022 - cell.com
Polychlorinated biphenyls (PCBs) are developmental neurotoxicants implicated as
environmental risk factors for neurodevelopmental disorders (NDDs). Here, we report the …

The role of endocrine-disrupting chemicals in uterine fibroid pathogenesis

MV Bariani, R Rangaswamy, H Siblini… - Current Opinion in …, 2020 - journals.lww.com
While research on EDCs and fibroids is still evolving, recent evidence suggests EDC
exposures may contribute to fibroid risk and progression. Further research is needed to …

New insights into the epigenetic regulation of inflammatory bowel disease

J Xu, H Xu, M Yang, Y Liang, Q Peng… - Frontiers in …, 2022 - frontiersin.org
Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the colonic mucosa.
Environmental factors, genetics, intestinal microbiota, and the immune system are all …

Epigallocatechin gallate for the treatment of benign and malignant gynecological diseases—Focus on epigenetic mechanisms

M Włodarczyk, M Ciebiera, G Nowicka, T Łoziński… - Nutrients, 2024 - mdpi.com
The most common malignant gynecologic diseases are cervical, uterine, ovarian, vaginal,
and vulvar cancer. Among them, ovarian cancer causes more deaths than any other cancer …