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Comprehensive review of uterine fibroids: developmental origin, pathogenesis, and treatment
Uterine fibroids are benign monoclonal neoplasms of the myometrium, representing the
most common tumors in women worldwide. To date, no long-term or noninvasive treatment …
most common tumors in women worldwide. To date, no long-term or noninvasive treatment …
A precision environmental health approach to prevention of human disease
Human health is determined by the interaction of our environment with the genome,
epigenome, and microbiome, which shape the transcriptomic, proteomic, and metabolomic …
epigenome, and microbiome, which shape the transcriptomic, proteomic, and metabolomic …
Targeting cholesterol metabolism in Cancer: From molecular mechanisms to therapeutic implications
J Lu, S Chen, X Bai, M Liao, Y Qiu, LL Zheng… - Biochemical …, 2023 - Elsevier
Cholesterol is an essential component of cell membranes and helps to maintain their
structure and function. Abnormal cholesterol metabolism has been linked to the …
structure and function. Abnormal cholesterol metabolism has been linked to the …
Role of endocrine-disrupting chemicals in the pathogenesis of non-alcoholic fatty liver disease: a comprehensive review
Non-alcoholic fatty liver disease (NAFLD) is considered the most common liver disorder,
affecting around 25% of the population worldwide. It is a complex disease spectrum, closely …
affecting around 25% of the population worldwide. It is a complex disease spectrum, closely …
Long-term health outcomes of early menarche in women: an umbrella review
JS Lee, YA Lee, CH Shin, DI Suh… - QJM: An International …, 2022 - academic.oup.com
Background There is limited comprehensive evidence on the potential association between
early menarche and subsequent health outcomes. Aim To evaluate the existing evidence for …
early menarche and subsequent health outcomes. Aim To evaluate the existing evidence for …
Kidney and epigenetic mechanisms of salt-sensitive hypertension
W Kawarazaki, T Fujita - Nature Reviews Nephrology, 2021 - nature.com
Dietary salt intake increases blood pressure (BP) but the salt sensitivity of BP differs
between individuals. The interplay of ageing, genetics and environmental factors, including …
between individuals. The interplay of ageing, genetics and environmental factors, including …
Placenta and fetal brain share a neurodevelopmental disorder DNA methylation profile in a mouse model of prenatal PCB exposure
Polychlorinated biphenyls (PCBs) are developmental neurotoxicants implicated as
environmental risk factors for neurodevelopmental disorders (NDDs). Here, we report the …
environmental risk factors for neurodevelopmental disorders (NDDs). Here, we report the …
The role of endocrine-disrupting chemicals in uterine fibroid pathogenesis
MV Bariani, R Rangaswamy, H Siblini… - Current Opinion in …, 2020 - journals.lww.com
While research on EDCs and fibroids is still evolving, recent evidence suggests EDC
exposures may contribute to fibroid risk and progression. Further research is needed to …
exposures may contribute to fibroid risk and progression. Further research is needed to …
New insights into the epigenetic regulation of inflammatory bowel disease
J Xu, H Xu, M Yang, Y Liang, Q Peng… - Frontiers in …, 2022 - frontiersin.org
Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the colonic mucosa.
Environmental factors, genetics, intestinal microbiota, and the immune system are all …
Environmental factors, genetics, intestinal microbiota, and the immune system are all …
Epigallocatechin gallate for the treatment of benign and malignant gynecological diseases—Focus on epigenetic mechanisms
M Włodarczyk, M Ciebiera, G Nowicka, T Łoziński… - Nutrients, 2024 - mdpi.com
The most common malignant gynecologic diseases are cervical, uterine, ovarian, vaginal,
and vulvar cancer. Among them, ovarian cancer causes more deaths than any other cancer …
and vulvar cancer. Among them, ovarian cancer causes more deaths than any other cancer …