Obtaining genetics insights from deep learning via explainable artificial intelligence

G Novakovsky, N Dexter, MW Libbrecht… - Nature Reviews …, 2023 - nature.com
Artificial intelligence (AI) models based on deep learning now represent the state of the art
for making functional predictions in genomics research. However, the underlying basis on …

Modern deep learning in bioinformatics

H Li, S Tian, Y Li, Q Fang, R Tan, Y Pan… - Journal of molecular …, 2020 - academic.oup.com
ML has been the main contributor to the recent resurgence of artificial intelligence. The most
essential piece in modern ML technology is DL. DL is founded on artificial neural networks …

Image super-resolution reconstruction based on feature map attention mechanism

Y Chen, L Liu, V Phonevilay, K Gu, R **a, J **e… - Applied …, 2021 - Springer
To improve the issue of low-frequency and high-frequency components from feature maps
being treated equally in existing image super-resolution reconstruction methods, the paper …

Omg: Towards effective graph classification against label noise

N Yin, L Shen, M Wang, X Luo, Z Luo… - IEEE Transactions on …, 2023 - ieeexplore.ieee.org
Graph classification is a fundamental problem with diverse applications in bioinformatics
and chemistry. Due to the intricate procedures of manual annotations in graphical domains …

Bidirectional learning for offline infinite-width model-based optimization

C Chen, Y Zhang, J Fu, XS Liu… - Advances in Neural …, 2022 - proceedings.neurips.cc
In offline model-based optimization, we strive to maximize a black-box objective function by
only leveraging a static dataset of designs and their scores. This problem setting arises in …

Genomics enters the deep learning era

E Routhier, J Mozziconacci - PeerJ, 2022 - peerj.com
The tremendous amount of biological sequence data available, combined with the recent
methodological breakthrough in deep learning in domains such as computer vision or …

SAResNet: self-attention residual network for predicting DNA-protein binding

LC Shen, Y Liu, J Song, DJ Yu - Briefings in Bioinformatics, 2021 - academic.oup.com
Abstract Knowledge of the specificity of DNA-protein binding is crucial for understanding the
mechanisms of gene expression, regulation and gene therapy. In recent years, deep …

Protein science meets artificial intelligence: a systematic review and a biochemical meta-analysis of an inter-field

J Villalobos-Alva, L Ochoa-Toledo… - … in Bioengineering and …, 2022 - frontiersin.org
Proteins are some of the most fascinating and challenging molecules in the universe, and
they pose a big challenge for artificial intelligence. The implementation of machine …

HCRNet: high-throughput circRNA-binding event identification from CLIP-seq data using deep temporal convolutional network

Y Yang, Z Hou, Y Wang, H Ma, P Sun… - Briefings in …, 2022 - academic.oup.com
Identifying genome-wide binding events between circular RNAs (circRNAs) and RNA-
binding proteins (RBPs) can greatly facilitate our understanding of functional mechanisms …

Genome-Wide Identification of C2H2 ZFPs and Functional Analysis of BRZAT12 under Low-Temperature Stress in Winter Rapeseed (Brassica rapa)

L Ma, J Xu, X Tao, J Wu, W Wang, Y Pu… - International Journal of …, 2022 - mdpi.com
Zinc-finger protein (ZFP) transcription factors are among the largest families of transcription
factors in plants. They participate in various biological processes such as apoptosis …