Ischemia-reperfusion injury: molecular mechanisms and therapeutic targets
Abstract Ischemia-reperfusion (I/R) injury paradoxically occurs during reperfusion following
ischemia, exacerbating the initial tissue damage. The limited understanding of the intricate …
ischemia, exacerbating the initial tissue damage. The limited understanding of the intricate …
Signaling pathways in rheumatoid arthritis: implications for targeted therapy
Q Ding, W Hu, R Wang, Q Yang, M Zhu, M Li… - Signal transduction and …, 2023 - nature.com
Rheumatoid arthritis (RA) is an incurable systemic autoimmune disease. Disease
progression leads to joint deformity and associated loss of function, which significantly …
progression leads to joint deformity and associated loss of function, which significantly …
Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer's mouse model
INTRODUCTION Alzheimer's disease (AD) is the most common form of age-related
dementia, characterized by cognitive impairment, neurodegeneration, β-amyloid (Aβ) …
dementia, characterized by cognitive impairment, neurodegeneration, β-amyloid (Aβ) …
The role of adult hippocampal neurogenesis in brain health and disease
Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by a number
of environmental and cell-intrinsic factors to adapt to environmental changes. Accumulating …
of environmental and cell-intrinsic factors to adapt to environmental changes. Accumulating …
Quiescence of adult mammalian neural stem cells: a highly regulated rest
N Urbán, IM Blomfield, F Guillemot - Neuron, 2019 - cell.com
Neural stem cells in the adult mammalian brain are the source of new neurons that
contribute to complex sensory and cognitive functions. Most adult neural stem cells are …
contribute to complex sensory and cognitive functions. Most adult neural stem cells are …
[HTML][HTML] Adult neurogenesis in the hippocampus: from stem cells to behavior
The dentate gyrus of the mammalian hippocampus continuously generates new neurons
during adulthood. These adult-born neurons become functionally active and are thought to …
during adulthood. These adult-born neurons become functionally active and are thought to …
Oxidative stress and regeneration
Regeneration is the process of replacing/restoring a damaged cell/tissue/organ to its full
function and is limited respecting complexity of specific organ structures and the level of …
function and is limited respecting complexity of specific organ structures and the level of …
Curcumin-loaded nanoparticles: A novel therapeutic strategy in treatment of central nervous system disorders
Curcumin as a hydrophobic polyphenol is extracted from the rhizome of Curcuma longa.
Curcumin is widely used as a dietary spice and a topical medication for the treatment of …
Curcumin is widely used as a dietary spice and a topical medication for the treatment of …
Astrocytes: a central element in neurological diseases
The neurone-centred view of the past disregarded or downplayed the role of astroglia as a
primary component in the pathogenesis of neurological diseases. As this concept is …
primary component in the pathogenesis of neurological diseases. As this concept is …
Restoring Wnt/β-catenin signaling is a promising therapeutic strategy for Alzheimer's disease
Alzheimer's disease (AD) is an aging-related neurological disorder characterized by
synaptic loss and dementia. Wnt/β-catenin signaling is an essential signal transduction …
synaptic loss and dementia. Wnt/β-catenin signaling is an essential signal transduction …