Structural basis of BAM-mediated outer membrane β-barrel protein assembly

C Shen, S Chang, Q Luo, KC Chan, Z Zhang, B Luo… - Nature, 2023 - nature.com
The outer membrane structure is common in Gram-negative bacteria, mitochondria and
chloroplasts, and contains outer membrane β-barrel proteins (OMPs) that are essential …

Maintenance of bacterial outer membrane lipid asymmetry: insight into MlaA

M Kaur, MP Mingeot-Leclercq - BMC microbiology, 2024 - Springer
The outer membrane (OM) of Gram-negative bacteria acts as an effective barrier to protect
against toxic compounds. By nature, the OM is asymmetric with the highly packed …

Targeting BAM for novel therapeutics against pathogenic gram-negative bacteria

C Overly Cottom, R Stephenson, L Wilson, N Noinaj - Antibiotics, 2023 - mdpi.com
The growing emergence of multidrug resistance in bacterial pathogens is an immediate
threat to human health worldwide. Unfortunately, there has not been a matching increase in …

Dynamic interplay between the periplasmic chaperone SurA and the BAM complex in outer membrane protein folding

B Schiffrin, JM Machin, TK Karamanos… - Communications …, 2022 - nature.com
Correct folding of outer membrane proteins (OMPs) into the outer membrane of Gram-
negative bacteria depends on delivery of unfolded OMPs to the β-barrel assembly …

Biogenesis of mitochondrial β‐barrel membrane proteins

I Ganesan, JV Busto, N Pfanner… - FEBS Open bio, 2024 - Wiley Online Library
β‐barrel membrane proteins in the mitochondrial outer membrane are crucial for mediating
the metabolite exchange between the cytosol and the mitochondrial intermembrane space …

The role of membrane destabilisation and protein dynamics in BAM catalysed OMP folding

P White, SF Haysom, MG Iadanza, AJ Higgins… - Nature …, 2021 - nature.com
The folding of β-barrel outer membrane proteins (OMPs) in Gram-negative bacteria is
catalysed by the β-barrel assembly machinery (BAM). How lateral opening in the β-barrel of …

ATP‐independent assembly machinery of bacterial outer membranes: BAM complex structure and function set the stage for next‐generation therapeutics

A George, AG Patil, R Mahalakshmi - Protein Science, 2024 - Wiley Online Library
Diderm bacteria employ β‐barrel outer membrane proteins (OMPs) as their first line of
communication with their environment. These OMPs are assembled efficiently in the …

Supramolecular assembly of protein building blocks: From folding to function

NH Kim, H Choi, ZM Shahzad, H Ki, J Lee, H Chae… - Nano …, 2022 - Springer
Several phenomena occurring throughout the life of living things start and end with proteins.
Various proteins form one complex structure to control detailed reactions. In contrast, one …

[HTML][HTML] Folding control in the path of type 5 secretion

N Dautin - Toxins, 2021 - mdpi.com
The type 5 secretion system (T5SS) is one of the more widespread secretion systems in
Gram-negative bacteria. Proteins secreted by the T5SS are functionally diverse (toxins …

New insights into the chloroplast outer membrane proteome and associated targeting pathways

M Fish, D Nash, A German, A Overton… - International Journal of …, 2022 - mdpi.com
Plastids are a dynamic class of organelle in plant cells that arose from an ancient
cyanobacterial endosymbiont. Over the course of evolution, most genes encoding plastid …