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Structural basis of BAM-mediated outer membrane β-barrel protein assembly
C Shen, S Chang, Q Luo, KC Chan, Z Zhang, B Luo… - Nature, 2023 - nature.com
The outer membrane structure is common in Gram-negative bacteria, mitochondria and
chloroplasts, and contains outer membrane β-barrel proteins (OMPs) that are essential …
chloroplasts, and contains outer membrane β-barrel proteins (OMPs) that are essential …
Maintenance of bacterial outer membrane lipid asymmetry: insight into MlaA
The outer membrane (OM) of Gram-negative bacteria acts as an effective barrier to protect
against toxic compounds. By nature, the OM is asymmetric with the highly packed …
against toxic compounds. By nature, the OM is asymmetric with the highly packed …
Targeting BAM for novel therapeutics against pathogenic gram-negative bacteria
C Overly Cottom, R Stephenson, L Wilson, N Noinaj - Antibiotics, 2023 - mdpi.com
The growing emergence of multidrug resistance in bacterial pathogens is an immediate
threat to human health worldwide. Unfortunately, there has not been a matching increase in …
threat to human health worldwide. Unfortunately, there has not been a matching increase in …
Dynamic interplay between the periplasmic chaperone SurA and the BAM complex in outer membrane protein folding
Correct folding of outer membrane proteins (OMPs) into the outer membrane of Gram-
negative bacteria depends on delivery of unfolded OMPs to the β-barrel assembly …
negative bacteria depends on delivery of unfolded OMPs to the β-barrel assembly …
Biogenesis of mitochondrial β‐barrel membrane proteins
I Ganesan, JV Busto, N Pfanner… - FEBS Open bio, 2024 - Wiley Online Library
β‐barrel membrane proteins in the mitochondrial outer membrane are crucial for mediating
the metabolite exchange between the cytosol and the mitochondrial intermembrane space …
the metabolite exchange between the cytosol and the mitochondrial intermembrane space …
The role of membrane destabilisation and protein dynamics in BAM catalysed OMP folding
P White, SF Haysom, MG Iadanza, AJ Higgins… - Nature …, 2021 - nature.com
The folding of β-barrel outer membrane proteins (OMPs) in Gram-negative bacteria is
catalysed by the β-barrel assembly machinery (BAM). How lateral opening in the β-barrel of …
catalysed by the β-barrel assembly machinery (BAM). How lateral opening in the β-barrel of …
ATP‐independent assembly machinery of bacterial outer membranes: BAM complex structure and function set the stage for next‐generation therapeutics
A George, AG Patil, R Mahalakshmi - Protein Science, 2024 - Wiley Online Library
Diderm bacteria employ β‐barrel outer membrane proteins (OMPs) as their first line of
communication with their environment. These OMPs are assembled efficiently in the …
communication with their environment. These OMPs are assembled efficiently in the …
Supramolecular assembly of protein building blocks: From folding to function
Several phenomena occurring throughout the life of living things start and end with proteins.
Various proteins form one complex structure to control detailed reactions. In contrast, one …
Various proteins form one complex structure to control detailed reactions. In contrast, one …
[HTML][HTML] Folding control in the path of type 5 secretion
N Dautin - Toxins, 2021 - mdpi.com
The type 5 secretion system (T5SS) is one of the more widespread secretion systems in
Gram-negative bacteria. Proteins secreted by the T5SS are functionally diverse (toxins …
Gram-negative bacteria. Proteins secreted by the T5SS are functionally diverse (toxins …
New insights into the chloroplast outer membrane proteome and associated targeting pathways
Plastids are a dynamic class of organelle in plant cells that arose from an ancient
cyanobacterial endosymbiont. Over the course of evolution, most genes encoding plastid …
cyanobacterial endosymbiont. Over the course of evolution, most genes encoding plastid …