Premature activation of digestive enzymes in the pancreas has been linked to development
of pancreatitis for more than a century. Recent development of novel models to study the …

The literature suggests that the physiological functions for which mitochondria sequester
Ca2+ are (1) to stimulate and control the rate of oxidative phosphorylation,(2) to induce the …

▪ Abstract The secretion of fluid and electrolytes by salivary gland acinar cells requires the
coordinated regulation of multiple water and ion transporter and channel proteins. Notably …

Calcium (Ca2+) is a ubiquitous intracellular messenger, controlling a diverse range of
cellular processes, such as gene transcription, muscle contraction and cell proliferation. The …

The gastrointestinal (GI) tract displays multiple motor patterns that move nutrients and
wastes through the body. Smooth muscle cells (SMCs) provide the forces necessary for GI …

The physical continuity of axons over long cellular distances poses challenges for their
maintenance. One organelle that faces this challenge is endoplasmic reticulum (ER); unlike …

The interactions between mathematics and physiology have a long and illustrious history, of
which the study of calcium signalling is but a small chapter. Nevertheless, for those involved …

Ca2+ is one of the most important messengers. It transmits signals inside living cells and
takes part in intercellular coordination. The dynamics of the Ca2+ concentration shows a …

We have identified three distinct groups of mitochondria in normal living pancreatic acinar
cells, located (i) in the peripheral basolateral region close to the plasma membrane,(ii) …

Cytosolic Ca2+ signals are crucial for the control of fluid and enzyme secretion from
exocrine glands. The highly polarized exocrine acinar cells have evolved sophisticated and …