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Principles and challenges of modeling temporal and spatial omics data
Studies with temporal or spatial resolution are crucial to understand the molecular dynamics
and spatial dependencies underlying a biological process or system. With advances in high …
and spatial dependencies underlying a biological process or system. With advances in high …
Computational approaches and challenges in spatial transcriptomics
The development of spatial transcriptomics (ST) technologies has transformed genetic
research from a single-cell data level to a two-dimensional spatial coordinate system and …
research from a single-cell data level to a two-dimensional spatial coordinate system and …
[HTML][HTML] A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain
The mammalian brain consists of millions to billions of cells that are organized into many cell
types with specific spatial distribution patterns and structural and functional properties …
types with specific spatial distribution patterns and structural and functional properties …
Molecularly defined and spatially resolved cell atlas of the whole mouse brain
In mammalian brains, millions to billions of cells form complex interaction networks to enable
a wide range of functions. The enormous diversity and intricate organization of cells have …
a wide range of functions. The enormous diversity and intricate organization of cells have …
The molecular cytoarchitecture of the adult mouse brain
The function of the mammalian brain relies upon the specification and spatial positioning of
diversely specialized cell types. Yet, the molecular identities of the cell types and their …
diversely specialized cell types. Yet, the molecular identities of the cell types and their …
A multimodal cell census and atlas of the mammalian primary motor cortex
Principal manuscript editors, Analysis coordination… - Nature, 2021 - nature.com
Here we report the generation of a multimodal cell census and atlas of the mammalian
primary motor cortex as the initial product of the BRAIN Initiative Cell Census Network …
primary motor cortex as the initial product of the BRAIN Initiative Cell Census Network …
[HTML][HTML] Spatially resolved cell atlas of the mouse primary motor cortex by MERFISH
A mammalian brain is composed of numerous cell types organized in an intricate manner to
form functional neural circuits. Single-cell RNA sequencing allows systematic identification …
form functional neural circuits. Single-cell RNA sequencing allows systematic identification …
Improved green and red GRAB sensors for monitoring spatiotemporal serotonin release in vivo
The serotonergic system plays important roles in both physiological and pathological
processes, and is a therapeutic target for many psychiatric disorders. Although several …
processes, and is a therapeutic target for many psychiatric disorders. Although several …
Morphological diversity of single neurons in molecularly defined cell types
Dendritic and axonal morphology reflects the input and output of neurons and is a defining
feature of neuronal types,, yet our knowledge of its diversity remains limited. Here, to …
feature of neuronal types,, yet our knowledge of its diversity remains limited. Here, to …
Single-neuron projectome of mouse prefrontal cortex
Prefrontal cortex (PFC) is the cognitive center that integrates and regulates global brain
activity. However, the whole-brain organization of PFC axon projections remains poorly …
activity. However, the whole-brain organization of PFC axon projections remains poorly …