Function and therapeutic value of astrocytes in neurological diseases
Astrocytes are abundant glial cells in the central nervous system (CNS) that perform diverse
functions in health and disease. Astrocyte dysfunction is found in numerous diseases …
functions in health and disease. Astrocyte dysfunction is found in numerous diseases …
Multiple sclerosis progression: time for a new mechanism-driven framework
Traditionally, multiple sclerosis has been categorised by distinct clinical descriptors—
relapsing-remitting, secondary progressive, and primary progressive—for patient care …
relapsing-remitting, secondary progressive, and primary progressive—for patient care …
[HTML][HTML] Ozanimod as induction and maintenance therapy for ulcerative colitis
WJ Sandborn, BG Feagan, G D'Haens… - … England Journal of …, 2021 - Mass Medical Soc
Background Ozanimod, a selective sphingosine-1-phosphate receptor modulator, is under
investigation for the treatment of inflammatory bowel disease. Methods We conducted a …
investigation for the treatment of inflammatory bowel disease. Methods We conducted a …
Diagnosis and treatment of multiple sclerosis: a review
MP McGinley, CH Goldschmidt, AD Rae-Grant - Jama, 2021 - jamanetwork.com
Importance Multiple sclerosis (MS) is an autoimmune-mediated neurodegenerative disease
of the central nervous system characterized by inflammatory demyelination with axonal …
of the central nervous system characterized by inflammatory demyelination with axonal …
Treatment of multiple sclerosis: a review
Multiple sclerosis (MS) is an autoimmune demyelinating and neurodegenerative disease of
the central nervous system, and the leading cause of nontraumatic neurological disability in …
the central nervous system, and the leading cause of nontraumatic neurological disability in …
The immune response in multiple sclerosis
S Rodríguez Murúa, MF Farez… - Annual Review of …, 2022 - annualreviews.org
Multiple sclerosis (MS) is a chronic autoimmune, inflammatory, and neurodegenerative
disease that affects the central nervous system (CNS). MS is characterized by immune …
disease that affects the central nervous system (CNS). MS is characterized by immune …
Identification of early neurodegenerative pathways in progressive multiple sclerosis
Progressive multiple sclerosis (MS) is characterized by unrelenting neurodegeneration,
which causes cumulative disability and is refractory to current treatments. Drug development …
which causes cumulative disability and is refractory to current treatments. Drug development …
Sphingosine 1-phosphate receptor modulators in multiple sclerosis and other conditions
Summary The sphingosine 1-phosphate (S1P) signalling pathways have important and
diverse functions. S1P receptors (S1PRs) have been proposed as a therapeutic target for …
diverse functions. S1P receptors (S1PRs) have been proposed as a therapeutic target for …
Ponesimod compared with teriflunomide in patients with relapsing multiple sclerosis in the active-comparator phase 3 OPTIMUM study: a randomized clinical trial
Importance To our knowledge, the Oral Ponesimod Versus Teriflunomide In Relapsing
Multiple Sclerosis (OPTIMUM) trial is the first phase 3 study comparing 2 oral disease …
Multiple Sclerosis (OPTIMUM) trial is the first phase 3 study comparing 2 oral disease …
Secondary progressive multiple sclerosis: new insights
In most cases, multiple sclerosis (MS) begins with a relapsing-remitting course followed by
insidious disability worsening that is independent from clinically apparent relapses and is …
insidious disability worsening that is independent from clinically apparent relapses and is …