Serial capture affinity purification (SCAP) is a powerful method to isolate a specific protein
complex. When combined with cross-linking mass spectrometry and computational …

Abnormal lipid metabolism plays crucial roles in the development of cancer. Spindlin 1
(SPIN1) involving the process of spindle organization and chromosomal stability serves as …

The orbitofrontal cortex (OFC) is a vital component of brain reward circuitry that is important
for reward seeking behavior. However, OFC-mediated molecular mechanisms underlying …

Spindlin1 is a histone reader with three Tudor-like domains and its transcriptional co-
activator activity could be attenuated by SPINDOC. The first two Tudors are involved in …

SPINDOC is tightly associated with the histone H3K4me3 effector protein SPIN1. To gain a
better understanding of the biological roles of SPINDOC, we identified its interacting …

Overgrowth syndromes can be caused by pathogenic genetic variants in epigenetic writers,
such as DNA and histone methyltransferases. However, no overgrowth disorder has …

The tandem Tudor-like domain-containing protein Spindlin1 (SPIN1) is a transcriptional
coactivator with critical functions in embryonic development and emerging roles in cancer …

Thyrotropin-releasing hormone (TRH) is known to activate several cellular signaling
pathway, but the activation of the TRH receptor (TRH-R) has not been reported to regulate …

Abstract Spindlin1 (SPIN1) is a unique multivalent histone modification reader that plays a
role in ribosomal RNA transcription, chromosome segregation, and tumorigenesis. However …

Purpose As a novel genetic biomarker, little information is available about the possible role
of SPINDOC in different malignant tumors and in hepatocellular carcinoma (HCC). Methods …