Collateral lethality: A unique type of synthetic lethality in cancers
Z Zhao, L Zhu, Y Luo, H Xu, Y Zhang - Pharmacology & Therapeutics, 2024 - Elsevier
Genetic interactions play crucial roles in cell-essential functions. Intrinsic genetic defects in
tumors typically involve gain-of-and loss-of-function mutations in tumor suppressor genes …
tumors typically involve gain-of-and loss-of-function mutations in tumor suppressor genes …
Interferon-ε loss is elusive 9p21 link to immune-cold tumors, resistant to immune-checkpoint therapy and endogenous CXCL9/10 induction
Introduction Copy-number (CN) loss of chromosome 9p, or parts thereof, impair immune
response and confer ICT resistance by direct elimination of immune-regulatory genes on this …
response and confer ICT resistance by direct elimination of immune-regulatory genes on this …