Abstract The 1, 2, 3-triazole ring is a major pharmacophore system among nitrogen-
containing heterocycles. These five-membered heterocyclic motifs with three nitrogen …

Anticancer agents are critical for the cancer treatment, but side effects and the drug
resistance associated with the currently used anticancer agents create an urgent need to …

Lung cancer is the most common malignancy and leads to around one-quarter of all cancer
deaths. Great advances have been achieved in the treatment of lung cancer with novel …

Nature products have been extensively used in the discovery and development of new
drugs, as the most important source of drugs. The triazole ring is one of main …

Covering: up to 2022 Podophyllotoxin (PTOX, 1), a kind of aryltetralin-type lignan, was first
discovered in the plant Podophyllum peltatum and its structure was clarified by W. Borsche …

Topoisomerases are very important enzymes that regulate DNA topology and are vital for
biological actions like DNA replication, transcription, and repair. The emergence and spread …

A simple and green synthesis of some fluorinated chalcone-triazole hybrids from
propargylated chalcones and organic azides catalyzed by cellulose supported copper …

A series of new pyrazolo-benzothiazole hybrids (7–26) were synthesised and screened for
their cytotoxic activity towards several cancer cell lines [colon (HT-29), prostate (PC-3), lung …

Podophyllotoxins and epipodophyllotoxins, possess excellent activity against both drug-
sensitive and drug-resistant even multidrug-resistant cancer cells via inhibition of tubulin …

Click chemistry has emerged as a valuable tool for rapid compound synthesis, presenting
notable advantages and convenience in the exploration of potential drug candidates. In …