Affinity-based release systems use transient interactions to sustain and control the release of
a therapeutic from a polymeric matrix. The most common affinity-based systems use heparin …

Current sustained delivery strategies of protein therapeutics are limited by the fragility of the
protein, resulting in minimal quantities of bioactive protein delivered. In order to achieve …

With the recent success in calculating protein structures from amino acid sequences using
artificial intelligence-based algorithms, an important next step is to decipher how dynamics …

SH3 domains are peptide recognition modules that mediate the assembly of diverse
biological complexes. We scanned billions of phage-displayed peptides to map the binding …

Protein–protein interactions (PPIs) between modular binding domains and their target
peptide motifs are thought to largely depend on the intrinsic binding specificities of the …

A major challenge to the characterization of intrinsically disordered regions (IDRs), which
are widespread in the proteome, but relatively poorly understood, is the identification of …

Chondroitinase ABC (ChABC) is a promising therapeutic for spinal cord injury as it can
degrade the glial scar that is detrimental to regrowth and repair. However, the sustained …

Phage tail fibres are elongated protein assemblies capable of specific recognition of
bacterial surfaces during the first step of viral infection,,–. The folding of these complex …

Mitochondrial apoptotic signaling cascades lead to the formation of the apoptosome, a 1.1-
MDa heptameric protein scaffold that recruits and activates the caspase-9 protease. Once …

How actin filaments are spatially organized and remodeled into diverse higher-order
networks in vivo is still not well understood. Here, we report an unexpected F-actin" …