4 (3H)-Quinazolinone derivatives: Promising antibacterial drug leads

S Gatadi, TV Lakshmi, S Nanduri - European journal of medicinal chemistry, 2019 - Elsevier
Emergence of drug resistance has created unmet medical need for the development of new
classes of antibiotics. Discovery of new antibacterial agents with new mode of action …

Design, synthesis, anticancer activity and docking studies of novel quinazoline-based thiazole derivatives as EGFR kinase inhibitors

MS Raghu, HA Swarup, T Shamala, BS Prathibha… - Heliyon, 2023 - cell.com
The in vitro anticancer efficacy of a new series of quinazoline-based thiazole derivatives was
explored. Three cancer cell lines, MCF-7, HepG2, and A548, as well as the normal Vero cell …

Halogen‐based quinazolin‐4(3H)‐one derivatives as MCF‐7 breast cancer inhibitors: Current developments and structure–activity relationship

R Upadhyay, P Tandel, AB Patel - Archiv der Pharmazie, 2025 - Wiley Online Library
Currently, cancer is a serious health challenge with predominance beyond restrictions.
Breast cancer remains one of the major contributors to cancer‐related morbidity and …

Design and synthesis of novel quinazolinone-pyrazole derivatives as potential α-glucosidase inhibitors: Structure-activity relationship, molecular modeling and kinetic …

F Azimi, H Azizian, M Najafi, F Hassanzadeh… - Bioorganic …, 2021 - Elsevier
In this study, a new series of quinazolinone-pyrazole hybrids were designed, synthesized
and screened for their α-glucosidase inhibitory activity. The results of the in vitro screening …

Synthesis of 1, 2, 3-triazole linked 4 (3H)-Quinazolinones as potent antibacterial agents against multidrug-resistant Staphylococcus aureus

S Gatadi, J Gour, M Shukla, G Kaul, S Das… - European Journal of …, 2018 - Elsevier
Methicillin and vancomycin resistant Staphylococcus aureus infections are an emerging
global health concern leading to increasing morbidity and mortality. Continuous increase in …

Investigation of biological activity of 2, 3-disubstituted quinazolin-4 (1 H)-ones against Mycobacterium tuberculosis and DNA via docking, spectroscopy and DFT …

CBP Kumar, MS Raghu, KNN Prasad… - New Journal of …, 2021 - pubs.rsc.org
A series of 2, 3-disubstituted quinazolin-4 (1H)-ones (3a–j) were screened for their
antimicrobial activity via the minimum inhibitory concentration method (MIC). The in vitro anti …

Synthesis of 6-substituted 3 (H)-quinazolin-4-ones and their antimicrobial activity

M Ziyadullaev, R Karimov, A Abdurazakhov… - Pharmaceutical …, 2023 - Springer
Three-step synthesis of 6-amino-3 (H)-quinazolin-4-ones has been performed. Initially, the
condensation of 3 (H)-quinazolin-4-one was carried out in the presence of anthranilic acid …

Chemical sensing ability of aminated graphdiyne (GDY-NH2) toward highly toxic organic volatile pollutants

A Allangawi, KA Jalal, K Ayub, MA Gilani… - Computational and …, 2023 - Elsevier
The detection of common environmental pollutants through chemical sensors has received
significant interest from the scientific community. Acetamide (AM), benzamide (BM) …

Development of chromone–pyrazole-based anticancer agents

MS Salem, EAE El-Helw, HAY Derbala - Russian Journal of Bioorganic …, 2020 - Springer
Abstract Chemical reactivity of 4-((6-chloro-4-oxo-4 H-chromen-3-yl) methylene)-2-
phenyloxazol-5 (4 H)-one towards nitrogen and sulfur nucleophiles, as well as bidentate …

Synthesis of quinazolinones via Cp* Co (iii)-catalyzed C–H functionalization of primary amides with oxadiazolones

X Wu, W Wu, S Fan, X Han, Z Wang, H Xu… - Organic & …, 2023 - pubs.rsc.org
Multi-heteroatom heterocycle synthesis through direct C–H bond activation is
methodologically appealing but synthetically challenging. An efficient double C–N bond …