4 (3H)-Quinazolinone derivatives: Promising antibacterial drug leads
Emergence of drug resistance has created unmet medical need for the development of new
classes of antibiotics. Discovery of new antibacterial agents with new mode of action …
classes of antibiotics. Discovery of new antibacterial agents with new mode of action …
Design, synthesis, anticancer activity and docking studies of novel quinazoline-based thiazole derivatives as EGFR kinase inhibitors
The in vitro anticancer efficacy of a new series of quinazoline-based thiazole derivatives was
explored. Three cancer cell lines, MCF-7, HepG2, and A548, as well as the normal Vero cell …
explored. Three cancer cell lines, MCF-7, HepG2, and A548, as well as the normal Vero cell …
Halogen‐based quinazolin‐4(3H)‐one derivatives as MCF‐7 breast cancer inhibitors: Current developments and structure–activity relationship
R Upadhyay, P Tandel, AB Patel - Archiv der Pharmazie, 2025 - Wiley Online Library
Currently, cancer is a serious health challenge with predominance beyond restrictions.
Breast cancer remains one of the major contributors to cancer‐related morbidity and …
Breast cancer remains one of the major contributors to cancer‐related morbidity and …
Design and synthesis of novel quinazolinone-pyrazole derivatives as potential α-glucosidase inhibitors: Structure-activity relationship, molecular modeling and kinetic …
In this study, a new series of quinazolinone-pyrazole hybrids were designed, synthesized
and screened for their α-glucosidase inhibitory activity. The results of the in vitro screening …
and screened for their α-glucosidase inhibitory activity. The results of the in vitro screening …
Synthesis of 1, 2, 3-triazole linked 4 (3H)-Quinazolinones as potent antibacterial agents against multidrug-resistant Staphylococcus aureus
Methicillin and vancomycin resistant Staphylococcus aureus infections are an emerging
global health concern leading to increasing morbidity and mortality. Continuous increase in …
global health concern leading to increasing morbidity and mortality. Continuous increase in …
Investigation of biological activity of 2, 3-disubstituted quinazolin-4 (1 H)-ones against Mycobacterium tuberculosis and DNA via docking, spectroscopy and DFT …
A series of 2, 3-disubstituted quinazolin-4 (1H)-ones (3a–j) were screened for their
antimicrobial activity via the minimum inhibitory concentration method (MIC). The in vitro anti …
antimicrobial activity via the minimum inhibitory concentration method (MIC). The in vitro anti …
Synthesis of 6-substituted 3 (H)-quinazolin-4-ones and their antimicrobial activity
M Ziyadullaev, R Karimov, A Abdurazakhov… - Pharmaceutical …, 2023 - Springer
Three-step synthesis of 6-amino-3 (H)-quinazolin-4-ones has been performed. Initially, the
condensation of 3 (H)-quinazolin-4-one was carried out in the presence of anthranilic acid …
condensation of 3 (H)-quinazolin-4-one was carried out in the presence of anthranilic acid …
Chemical sensing ability of aminated graphdiyne (GDY-NH2) toward highly toxic organic volatile pollutants
The detection of common environmental pollutants through chemical sensors has received
significant interest from the scientific community. Acetamide (AM), benzamide (BM) …
significant interest from the scientific community. Acetamide (AM), benzamide (BM) …
Development of chromone–pyrazole-based anticancer agents
Abstract Chemical reactivity of 4-((6-chloro-4-oxo-4 H-chromen-3-yl) methylene)-2-
phenyloxazol-5 (4 H)-one towards nitrogen and sulfur nucleophiles, as well as bidentate …
phenyloxazol-5 (4 H)-one towards nitrogen and sulfur nucleophiles, as well as bidentate …
Synthesis of quinazolinones via Cp* Co (iii)-catalyzed C–H functionalization of primary amides with oxadiazolones
X Wu, W Wu, S Fan, X Han, Z Wang, H Xu… - Organic & …, 2023 - pubs.rsc.org
Multi-heteroatom heterocycle synthesis through direct C–H bond activation is
methodologically appealing but synthetically challenging. An efficient double C–N bond …
methodologically appealing but synthetically challenging. An efficient double C–N bond …