Relationship of nonalcoholic fatty liver disease and heart failure with preserved ejection fraction
Although there is an established bidirectional relationship between heart failure with
reduced ejection fraction and liver disease, the association between heart failure with …
reduced ejection fraction and liver disease, the association between heart failure with …
[HTML][HTML] Potential effects and application prospect of angiotensin receptor-neprilysin inhibitor in diabetic kidney disease
X Zhang, Y Zhou, R Ma - Journal of Diabetes and its Complications, 2022 - Elsevier
Diabetic kidney disease (DKD) is one of the main causes of end-stage renal disease
(ESRD) and all-cause mortality in diabetic patients, despite the extensive use of angiotensin …
(ESRD) and all-cause mortality in diabetic patients, despite the extensive use of angiotensin …
LCZ696 attenuates sepsis-induced liver dysfunction in rats; the role of oxidative stress, apoptosis, and JNK1/2-P38 signaling pathways
RH Mohyeldin, R Alaaeldin, EE Sharata, ME Attya… - Life Sciences, 2023 - Elsevier
Aim Sepsis is a serious inflammatory response to infection with an annual incidence rate of>
48 million cases and 11 million fatalities worldwide. Furthermore, sepsis remains the world's …
48 million cases and 11 million fatalities worldwide. Furthermore, sepsis remains the world's …
The angiotensin receptor neprilysin inhibitor LCZ696 attenuates renal fibrosis via ASK1/JNK/p38 MAPK-mediated apoptosis in unilateral ureteral obstruction
J Ding, S Cui, SY Li, LY Cui, QY Nan, XJ Lin, MY Xuan… - Plos one, 2023 - journals.plos.org
The angiotensin receptor neprilysin inhibitor LCZ696 affords superior cardioprotection and
renoprotection compared with renin-angiotensin blockade monotherapy, but the underlying …
renoprotection compared with renin-angiotensin blockade monotherapy, but the underlying …
The Angiotensin II Receptor Neprilysin Inhibitor LCZ696 Inhibits the NLRP3 Inflammasome By Reducing Mitochondrial Dysfunction in Macrophages and Alleviates …
HW Chiu, CH Wu, WY Lin, WT Wong, WC Tsai, HT Hsu… - Inflammation, 2024 - Springer
The intracellular sensor protein complex known as the NACHT, LRR, and PYD domain-
containing protein 3 (NLRP3) inflammasome plays a crucial role in regulating inflammatory …
containing protein 3 (NLRP3) inflammasome plays a crucial role in regulating inflammatory …
Crocin treatment exerts anti-inflammatory and anti-oxidative effects in liver tissue damage of pinealectomized diabetic rats
Diabetes mellitus (DM) is a chronic metabolic disorder with an increasing global prevalence
that leads to significant morbidity and mortality. The liver plays a vital role in glycemic …
that leads to significant morbidity and mortality. The liver plays a vital role in glycemic …
[HTML][HTML] Sacubitril/valsartan combination enhanced cardiac glycophagy and prevented the progression of murine diabetic cardiomyopathy
Background Diabetic cardiomyopathy (DCM) is linked to disturbance in cardiac glucose
handling and increased cardiac glycogen storage. This study tested the potential role of …
handling and increased cardiac glycogen storage. This study tested the potential role of …
[HTML][HTML] Protective role of Dodonaea viscosa extract against streptozotocin-induced hepatotoxicity and nephrotoxicity in rats
Previous investigations have shown that D. viscosa herbal extract is often used to treat a
variety of diseases. Therefore, the purpose of this study was to investigate any additional …
variety of diseases. Therefore, the purpose of this study was to investigate any additional …
Cardiometabolic effects of sacubitril/valsartan in a rat model of heart failure with preserved ejection fraction
S Moraña-Fernández, X Vázquez-Abuín… - Biochemical …, 2024 - Elsevier
The promising results obtained in the PARADIGM-HF trial prompted the approval of
sacubitril/valsartan (SAC/VAL) as a first-in-class treatment for heart failure with reduced …
sacubitril/valsartan (SAC/VAL) as a first-in-class treatment for heart failure with reduced …
[HTML][HTML] Sacubitril/Valsartan Combination Partially Improves Cardiac Systolic, but Not Diastolic, Function through β-AR Responsiveness in a Rat Model of Type 2 …
BR Erdogan, ZE Yesilyurt-Dirican… - International Journal of …, 2024 - mdpi.com
Cardiovascular complications are the major cause of diabetes mellitus-related morbidity and
mortality. Increased renin–angiotensin–aldosterone system activity and decreased β …
mortality. Increased renin–angiotensin–aldosterone system activity and decreased β …