Pharmacological targeting of endoplasmic reticulum stress in disease
The accumulation of misfolded proteins in the endoplasmic reticulum (ER) leads to ER
stress, resulting in activation of the unfolded protein response (UPR) that aims to restore …
stress, resulting in activation of the unfolded protein response (UPR) that aims to restore …
The unfolded protein response and cell fate control
The secretory capacity of a cell is constantly challenged by physiological demands and
pathological perturbations. To adjust and match the protein-folding capacity of the …
pathological perturbations. To adjust and match the protein-folding capacity of the …
Proteostasis control by the unfolded protein response
Stress induced by accumulation of misfolded proteins in the endoplasmic reticulum is
observed in many physiological and pathological conditions. To cope with endoplasmic …
observed in many physiological and pathological conditions. To cope with endoplasmic …
Homeostasis control in health and disease by the unfolded protein response
Cells rely on the endoplasmic reticulum (ER) to fold and assemble newly synthesized
transmembrane and secretory proteins—essential for cellular structure–function and for both …
transmembrane and secretory proteins—essential for cellular structure–function and for both …
Endoplasmic reticulum stress–activated cell reprogramming in oncogenesis
Stress induced by the accumulation of unfolded proteins in the endoplasmic reticulum (ER)
is observed in many human diseases, including cancers. Cellular adaptation to ER stress is …
is observed in many human diseases, including cancers. Cellular adaptation to ER stress is …
ADP-ribosylation of RNA in mammalian cells is mediated by TRPT1 and multiple PARPs
RNA function relies heavily on posttranscriptional modifications. Recently, it was shown that
certain PARPs and TRPT1 can ADP-ribosylate RNA in vitro. Traditionally, intracellular ADP …
certain PARPs and TRPT1 can ADP-ribosylate RNA in vitro. Traditionally, intracellular ADP …
Endoplasmic reticulum stress in metabolic liver diseases and hepatic fibrosis
JL Maiers, H Malhi - Seminars in liver disease, 2019 - thieme-connect.com
Endoplasmic reticulum (ER) stress is a major contributor to liver disease and hepatic
fibrosis, but the role it plays varies depending on the cause and progression of the disease …
fibrosis, but the role it plays varies depending on the cause and progression of the disease …
Regulated IRE1α-dependent decay (RIDD)-mediated reprograming of lipid metabolism in cancer
IRE1α is constitutively active in several cancers and can contribute to cancer progression.
Activated IRE1α cleaves XBP1 mRNA, a key step in production of the transcription factor …
Activated IRE1α cleaves XBP1 mRNA, a key step in production of the transcription factor …
Dual IRE 1 RN ase functions dictate glioblastoma development
Proteostasis imbalance is emerging as a major hallmark of cancer, driving tumor
aggressiveness. Evidence suggests that the endoplasmic reticulum (ER), a major site for …
aggressiveness. Evidence suggests that the endoplasmic reticulum (ER), a major site for …
Metazoan tRNA introns generate stable circular RNAs in vivo
We report the discovery of a class of abundant circular noncoding RNAs that are produced
during metazoan tRNA splicing. These transcripts, termed tRNA intronic circular (tric) RNAs …
during metazoan tRNA splicing. These transcripts, termed tRNA intronic circular (tric) RNAs …