Polymeric delivery of therapeutic nucleic acids

R Kumar, CF Santa Chalarca, MR Bockman… - Chemical …, 2021 - ACS Publications
The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

Block copolymer micelles in nanomedicine applications

H Cabral, K Miyata, K Osada, K Kataoka - Chemical reviews, 2018 - ACS Publications
Polymeric micelles are demonstrating high potential as nanomedicines capable of
controlling the distribution and function of loaded bioactive agents in the body, effectively …

Gene therapy and DNA delivery systems

D Ibraheem, A Elaissari, H Fessi - International journal of pharmaceutics, 2014 - Elsevier
Gene therapy is a promising new technique for treating many serious incurable diseases,
such as cancer and genetic disorders. The main problem limiting the application of this …

Block copolymer micelles for drug delivery: design, characterization and biological significance

K Kataoka, A Harada, Y Nagasaki - Advanced drug delivery reviews, 2012 - Elsevier
Recently, colloidal carrier systems have been receiving much attention in the field of drug
targeting because of their high loading capacity for drugs as well as their unique disposition …

Nanocarrier mediated delivery of siRNA/miRNA in combination with chemotherapeutic agents for cancer therapy: current progress and advances

NS Gandhi, RK Tekade, MB Chougule - Journal of Controlled Release, 2014 - Elsevier
Chemotherapeutic agents have certain limitations when it comes to treating cancer, the most
important being severe side effects along with multidrug resistance developed against them …

Nanogels as pharmaceutical carriers: finite networks of infinite capabilities

AV Kabanov, SV Vinogradov - … Chemie International Edition, 2009 - Wiley Online Library
Nanogels are swollen nanosized networks composed of hydrophilic or amphiphilic polymer
chains. They are developed as carriers for the transport of drugs, and can be designed to …

Gene delivery by lipoplexes and polyplexes

CT de Ilarduya, Y Sun, N Düzgüneş - European journal of pharmaceutical …, 2010 - Elsevier
Gene therapy has emerged as a promising approach for the treatment or prevention of
acquired and genetic diseases. At the present time, major somatic gene transfer approaches …

Passive and active drug targeting: drug delivery to tumors as an example

VP Torchilin - Drug delivery, 2010 - Springer
The paradigm of using nanoparticulate pharmaceutical carriers has been well established
over the past decade, both in pharmaceutical research and in the clinical setting. Drug …

Poly (ethylenimine) and its role in gene delivery

WT Godbey, KK Wu, AG Mikos - Journal of controlled release, 1999 - Elsevier
Since the first published examination of poly (ethylenimine)(PEI) as a gene delivery vehicle,
there has been a flurry of research aimed at this polycation and its role in gene therapy …

Polyethylenimine-based non-viral gene delivery systems

U Lungwitz, M Breunig, T Blunk, A Göpferich - European Journal of …, 2005 - Elsevier
Gene therapy has become a promising strategy for the treatment of many inheritable or
acquired diseases that are currently considered incurable. Non-viral vectors have attracted …