Nutrigenomics and nutrigenetics: the emerging faces of nutrition

DM Mutch, W Wahli, G Williamson - The FASEB journal, 2005 - Wiley Online Library
The recognition that nutrients have the ability to interact and modulate molecular
mechanisms underlying an organism's physiological functions has prompted a revolution in …

PPARγ AND GLUCOSE HOMEOSTASIS

F Picard, J Auwerx - Annual review of nutrition, 2002 - annualreviews.org
▪ Abstract Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear receptor
involved in the control of metabolism. Research on PPARγ is oriented towards …

Genetics of leptin and obesity: a HuGE review

V Paracchini, P Pedotti, E Taioli - American journal of …, 2005 - academic.oup.com
Leptin is an important regulator of the mass of adipose tissue and of body weight; it operates
by inhibiting food intake and stimulating energy expenditure. Some polymorphic genes …

The peroxisome proliferator-activated receptor-γ2 Pro12Ala polymorphism

M Stumvoll, H Haring - Diabetes, 2002 - Am Diabetes Assoc
Peroxisome proliferator-activated receptor (PPAR)-γ is a transcription factor with a key role
in adipocyte differentiation. The Ala allele of the common Pro12Ala polymorphism in the …

Genetic influences in gastro-oesophageal reflux disease: a twin study

I Mohammed, LF Cherkas, SA Riley… - Journal of Medical …, 2003 - jmg.bmj.com
Background: A number of families have been described which include multiple members
with symptomatic, endoscopic, or complicated gastro-oesophageal reflux disease (GORD) …

PPARadigms and PPARadoxes: expanding roles for PPARγ in the control of lipid metabolism

R Walczak, P Tontonoz - Journal of lipid research, 2002 - ASBMB
The nuclear receptor PPARγ is a central regulator of adipose tissue development and an
important modulator of gene expression in a number of specialized cell types including …

Peroxisome proliferator-activated receptor-γ calls for activation in moderation: lessons from genetics and pharmacology

C Knouff, J Auwerx - Endocrine reviews, 2004 - academic.oup.com
The peroxisome proliferator-activated receptor γ (PPARγ) is a prototypical member of the
nuclear receptor superfamily and integrates the control of energy, lipid, and glucose …

Effect of the peroxisome proliferator activated receptor-γ gene Pro12Ala variant on body mass index: a meta-analysis

S Masud, S Ye - Journal of medical genetics, 2003 - jmg.bmj.com
Peroxisome proliferator activated receptor-c (PPAR-c) is a transcription factor abundantly
expressed in adipocytes, and plays a key role in the regulation of adipocyte differentiation …

G allele of the rs1801282 polymorphism in PPARγ gene confers an increased risk of obesity and hypercholesterolemia, while T allele of the rs3856806 polymorphism …

S Li, C He, H Nie, Q Pang, R Wang, Z Zeng… - Frontiers in …, 2022 - frontiersin.org
Background The relationships between the rs1801282 and rs3856806 polymorphisms in
nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) gene and …

The human obesity gene map: the 2001 update

T Rankinen, L Pérusse, SJ Weisnagel… - Obesity …, 2002 - Wiley Online Library
This report constitutes the eighth update of the human obesity gene map, incorporating
published results up to the end of October 2001. Evidence from the rodent and human …