Schistosomiasis—from immunopathology to vaccines

DP McManus, R Bergquist, P Cai… - Seminars in …, 2020 - Springer
Schistosomiasis (bilharzia) is a neglected tropical disease caused by trematode worms of
the genus Schistosoma. The transmission cycle involves human (or other mammalian) water …

Urogenital schistosomiasis—history, pathogenesis, and bladder cancer

LL Santos, J Santos, MJ Gouveia, C Bernardo… - Journal of Clinical …, 2021 - mdpi.com
Schistosomiasis is the most important helminthiasis worldwide in terms of morbidity and
mortality. Most of the infections occurs in Africa, which about two thirds are caused by …

Chromosome-level genome of Schistosoma haematobium underpins genome-wide explorations of molecular variation

AJ Stroehlein, PK Korhonen, VV Lee, SA Ralph… - PLoS …, 2022 - journals.plos.org
Urogenital schistosomiasis is caused by the blood fluke Schistosoma haematobium and is
one of the most neglected tropical diseases worldwide, afflicting> 100 million people. It is …

Diverging patterns of introgression from Schistosoma bovis across S. haematobium African lineages

O Rey, E Toulza, C Chaparro, JF Allienne… - PLoS …, 2021 - journals.plos.org
Hybridization is a fascinating evolutionary phenomenon that raises the question of how
species maintain their integrity. Inter-species hybridization occurs between certain …

Morphological and genomic characterisation of the Schistosoma hybrid infecting humans in Europe reveals admixture between Schistosoma haematobium and …

J Kincaid-Smith, A Tracey… - PLoS neglected …, 2021 - journals.plos.org
Schistosomes cause schistosomiasis, the world's second most important parasitic disease
after malaria in terms of public health and social-economic impacts. A peculiar feature of …

Chromosome-scale genome of the human blood fluke Schistosoma mekongi and its implications for public health

M Zhou, L Xu, D Xu, W Chen, J Khan, Y Hu… - Infectious Diseases of …, 2023 - Springer
Background Schistosoma mekongi is a human blood fluke causing schistosomiasis that
threatens approximately 1.5 million humans in the world. Nonetheless, the limited available …

Large CRISPR-Cas-induced deletions in the oxamniquine resistance locus of the human parasite Schistosoma mansoni

G Sankaranarayanan, A Coghlan… - Wellcome open …, 2021 - pmc.ncbi.nlm.nih.gov
Background. At least 250 million people worldwide suffer from schistosomiasis, caused by
Schistosoma worms. Genome sequences for several Schistosoma species are available …

Schistosoma haematobium Extracellular Vesicle Proteins Confer Protection in a Heterologous Model of Schistosomiasis

GG Mekonnen, BA Tedla, D Pickering, L Becker… - Vaccines, 2020 - mdpi.com
Helminth parasites release extracellular vesicles which interact with the surrounding host
tissues, mediating host–parasite communication and other fundamental processes of …

[HTML][HTML] A chromosome-level genome of the human blood fluke Schistosoma japonicum identifies the genomic basis of host-switching

F Luo, W Yang, M Yin, X Mo, Y Pang, C Sun, B Zhu… - Cell reports, 2022 - cell.com
The evolution and adaptation of S. japonicum, a zoonotic parasite that causes human
schistosomiasis, remain unclear because of the lack of whole-genome data. We construct a …

Phylogenomic Analysis of 155 Helminth Species Reveals Widespread Absence of Oxygen Metabolic Capacity

E Collington, B Lobb, NA Mazen… - Genome Biology and …, 2023 - academic.oup.com
The terminal electron acceptor of most aerobic respiratory chains, cytochrome c oxidase
(COX), has been highly conserved throughout evolution, from aerobic prokaryotes to …