Is tendon pathology a continuum? A pathology model to explain the clinical presentation of load-induced tendinopathy

JL Cook, CR Purdam - British journal of sports medicine, 2009 - bjsm.bmj.com
Overuse tendinopathy is problematic to manage clinically. People of different ages with
tendons under diverse loads present with varying degrees of pain, irritability, and capacity to …

Pathogenesis of tendinopathies: inflammation or degeneration?

M Abate, K Gravare Silbernagel, C Siljeholm… - Arthritis research & …, 2009 - Springer
The intrinsic pathogenetic mechanisms of tendinopathies are largely unknown and whether
inflammation or degeneration has the prominent role is still a matter of debate. Assuming …

Clinical risk factors for Achilles tendinopathy: a systematic review

AC Van der Vlist, SJ Breda, EHG Oei… - British journal of sports …, 2019 - bjsm.bmj.com
Background Achilles tendinopathy is a common problem, but its exact aetiology remains
unclear. Objective To evaluate the association between potential clinical risk factors and …

The past, present and future in scaffold-based tendon treatments

AJ Lomas, CNM Ryan, A Sorushanova… - Advanced drug delivery …, 2015 - Elsevier
Tendon injuries represent a significant clinical burden on healthcare systems worldwide. As
the human population ages and the life expectancy increases, tendon injuries will become …

Genetic risk factors for anterior cruciate ligament ruptures: COL1A1 gene variant

M Posthumus, AV September, M Keegan… - British journal of sports …, 2009 - bjsm.bmj.com
Background: Anterior cruciate ligament (ACL) ruptures are considered the most severe
injury sustained in sports. Although various intrinsic and extrinsic risk factors have been …

Variants within the MMP3 gene are associated with Achilles tendinopathy: possible interaction with the COL5A1 gene

SM Raleigh, L Van der Merwe, WJ Ribbans… - British journal of sports …, 2009 - bjsm.bmj.com
Objectives: Sequence variation within the COL5A1 and TNC genes are known to associate
with Achilles tendinopathy. The primary aim of this case-control genetic association study …

Genetic risk factors for musculoskeletal soft tissue injuries

M Collins, SM Raleigh - Genetics and sports, 2009 - karger.com
Acute and overuse musculoskeletal soft tissues injuries are common as a result of
participating in specific physical or workplace activities. Multiple risk factors, including …

[HTML][HTML] The genetics of sports injuries and athletic performance

N Maffulli, K Margiotti, UG Longo… - … and tendons journal, 2013 - ncbi.nlm.nih.gov
Purpose: in the last two decades, several evidences have been provided to support the
relationship between single nucleotide polymorphisms and the susceptibility to develop …

The association between the COL12A1 gene and anterior cruciate ligament ruptures

M Posthumus, AV September… - British journal of sports …, 2010 - bjsm.bmj.com
Background Anterior cruciate ligament (ACL) ruptures are among the most severe
musculoskeletal soft tissue injuries. However, the exact mechanisms which cause these …

Tendon and ligament genetics: How do they contribute to disease and injury? A narrative review

WJ Ribbans, AV September, M Collins - Life, 2022 - mdpi.com
A significant proportion of patients requiring musculoskeletal management present with
tendon and ligament pathology. Our understanding of the intrinsic and extrinsic mechanisms …