The composition, functions, and regulation of the budding yeast kinetochore

S Biggins - Genetics, 2013 - academic.oup.com
The propagation of all organisms depends on the accurate and orderly segregation of
chromosomes in mitosis and meiosis. Budding yeast has long served as an outstanding …

Regulation of outer kinetochore Ndc80 complex-based microtubule attachments by the central kinetochore Mis12/MIND complex

EM Kudalkar, EA Scarborough… - Proceedings of the …, 2015 - National Acad Sciences
Multiple protein subcomplexes of the kinetochore cooperate as a cohesive molecular unit
that forms load-bearing microtubule attachments that drive mitotic chromosome movements …

Pericentric chromatin loops function as a nonlinear spring in mitotic force balance

AD Stephens, RA Haggerty, PA Vasquez, L Vicci… - Journal of Cell …, 2013 - rupress.org
The mechanisms by which sister chromatids maintain biorientation on the metaphase
spindle are critical to the fidelity of chromosome segregation. Active force interplay exists …

Complex fluids and soft structures in the human body

PA Vasquez, MG Forest - Complex fluids in biological systems: Experiment …, 2014 - Springer
The human body is a composite of diverse materials able to perform specific functions. Few
of these materials are simple liquids or solids; rather they share both liquid-like and solid …

Direct measurement of the strength of microtubule attachment to yeast centrosomes

KK Fong, KK Sarangapani, EC Yusko… - Molecular Biology of …, 2017 - Am Soc Cell Biol
Centrosomes, or spindle pole bodies (SPBs) in yeast, are vital mechanical hubs that
maintain load-bearing attachments to microtubules during mitotic spindle assembly, spindle …

[BOOK][B] The Role of Outer Kinetochore Proteins in Forming Load-Bearing Interactions with the Dynamic Microtubule Tip

RL Flores - 2021 - search.proquest.com
Mitosis, a biological process where newly duplicated DNA is condensed and segregated
between a dividing cell, is an essential process for all eukaryotic systems. During mitosis …

Building a Functional Kinetochore: From Microtubule to Centromere

GE Hamilton - 2020 - digital.lib.washington.edu
Equal partitioning of duplicated chromosomes between daughter cells is a microtubule-
mediated process essential to eukaryotic life. A multi-protein machine, the kinetochore …

Computational Investigation of Ska Complex-Tubulin Molecular Interactions to Shed Light on Force Generation Mechanisms in Kinetochore-Microtubule Junctions

H Khoshkhoo Gilvaei - 2019 - webthesis.biblio.polito.it
Microtubules (MTs) are involved in several cellular processes and play a key role during
mitosis, forming the mitotic spindle which is able to divide the chromosomes. The connection …

Regulation of microtubule nucleation and attachment to spindle pole bodies

KK Fong - 2016 - digital.lib.washington.edu
The precise regulation and coordination of the mitotic spindle is vital for accurate
chromosomal segregation within a dividing cell. The centrosome is the microtubule …

Studies of Kinetochore Mechanobiology in Drosophila

S Cane - 2016 - scholarworks.umass.edu
Kinetochores are large multiprotein structures through which chromosomes engage with the
microtubules of the mitotic spindle. All kinetochore pairs must ultimately adopt a bioriented …