Flavonoids, terpenoids, and polyketide antibiotics: Role of glycosylation and biocatalytic tactics in engineering glycosylation

UM Vasudevan, EY Lee - Biotechnology advances, 2020 - Elsevier
Flavonoids, terpenoids, and polyketides are structurally diverse secondary metabolites used
widely as pharmaceuticals and nutraceuticals. Most of these molecules exist in nature as …

Engineered production of bioactive polyphenolic O-glycosides

J Ren, CD Barton, J Zhan - Biotechnology Advances, 2023 - Elsevier
Polyphenolic compounds (such as quercetin and resveratrol) possess potential medicinal
values due to their various bioactivities, but poor water solubility hinders their health benefits …

Recent advances in the metabolic engineering of yeasts for ginsenoside biosynthesis

LL Chu, JAV Montecillo, H Bae - Frontiers in Bioengineering and …, 2020 - frontiersin.org
Ginsenosides are a group of glycosylated triterpenes isolated from Panax species.
Ginsenosides are promising candidates for the prevention and treatment of cancer as well …

Tailored functionalization of natural phenols to improve biological activity

B Floris, P Galloni, V Conte, F Sabuzi - Biomolecules, 2021 - mdpi.com
Phenols are widespread in nature, being the major components of several plants and
essential oils. Natural phenols' anti-microbial, anti-bacterial, anti-oxidant, pharmacological …

Advances in biochemistry and the biotechnological production of taxifolin and its derivatives

NH Thuan, A Shrestha, NT Trung… - Biotechnology and …, 2022 - Wiley Online Library
Taxifolin (dihydroquercetin) and its derivatives are medicinally important flavanonols with a
wide distribution in plants. These compounds have been isolated from various plants, such …

Chemical and molecular characterization of metabolites from Flavobacterium sp.

V Enisoglu-Atalay, B Atasever-Arslan, B Yaman… - PloS one, 2018 - journals.plos.org
In this study, a Flavobacterium sp. is isolated from natural spring, and identified using
molecular techniques. Extracellular and intracellular secondary metabolites are identified …

Escherichia coli modular coculture system for resveratrol glucosides production

NH Thuan, NT Trung, NX Cuong, D Van Cuong… - World Journal of …, 2018 - Springer
In bio-based fermentation, the overall bioprocess efficiency is significantly affected by the
metabolic burden associated with the expression of complete biosynthetic pathway as well …

Constitutive Polyphenols in Blades and Veins of Grapevine (Vitis vinifera L.) Healthy Leaves

O Kedrina-Okutan, V Novello, T Hoffmann… - Journal of agricultural …, 2018 - ACS Publications
Despite the economic importance and the diffusion of grapevine cultivation worldwide, little
is known about leaf chemical composition. We characterized the phenolic composition of …

[HTML][HTML] High level production of flavonoid rhamnosides by metagenome-derived glycosyltransferase C in Escherichia coli utilizing dextrins of starch as a single …

C Ruprecht, F Bönisch, N Ilmberger, TV Heyer… - Metabolic …, 2019 - Elsevier
Flavonoids exert a wide variety of biological functions that are highly attractive for the
pharmaceutical and healthcare industries. However, their application is often limited by low …

Improved production of 1-deoxynojirymicin in Escherichia coli through metabolic engineering

V Rayamajhi, D Dhakal, AK Chaudhary… - World Journal of …, 2018 - Springer
Abstract Azasugars, such as 1-deoxynojirymicin (1-DNJ), are associated with diverse
pharmaceutical applications, such as antidiabetic, anti-obesity, anti-HIV, and antitumor …