Fibrosis is defined as an excessive deposition of connective tissue components and can
affect virtually every organ system, including the skin, lungs, liver and kidney. Fibrotic tissue …

From the clinical standpoint, systemic sclerosis (SSc) is characterized by skin and internal
organ fibrosis, diffuse fibroproliferative vascular modifications, and autoimmunity. Clinical …

Skin and lung fibrosis in systemic sclerosis (SSc) is driven by myofibroblasts, alpha-smooth
muscle actin expressing cells. The number of myofibroblasts in SSc skin correlates with the …

Systemic autoimmune rheumatic diseases (SARDs) exhibit extensive heterogeneity in
clinical presentation, disease course, and treatment response. Therefore, precision …

Tissue fibrosis is the deposition of excessive extracellular matrix and can occur as part of the
body's natural wound healing process upon injury, or as a consequence of diseases such as …

Objectives Determine global skin transcriptome patterns of early diffuse systemic sclerosis
(SSc) and how they differ from later disease. Methods Skin biopsy RNA from 48 patients in …

Fibroblasts are polymorphic cells with pleiotropic roles in organ morphogenesis, tissue
homeostasis and immune responses. In fibrotic diseases, fibroblasts synthesize abundant …

Interferon regulatory factor (IRF) 7 was originally identified as master transcriptional factor
that produced IFN-I and regulated innate immune response, subsequent studies have …

Diffuse cutaneous systemic sclerosis (dcSSc) is associated with high mortality resulting from
early internal-organ involvement. Clinicians therefore tend to focus on early diagnosis and …

The role played by T1 IFN and its regulatory genes in SSc is becoming increasingly evident
and strikingly similar to the role observed in SLE. This observation, together with the benefit …