Adaptive deep brain stimulation: From experimental evidence toward practical implementation
Closed‐loop adaptive deep brain stimulation (aDBS) can deliver individualized therapy at
an unprecedented temporal precision for neurological disorders. This has the potential to …
an unprecedented temporal precision for neurological disorders. This has the potential to …
Deep brain stimulation in movement disorders: from experimental surgery to evidence‐based therapy
Deep brain stimulation (DBS) of 3 different targets is the most important therapeutic
innovation of the past 30 years for patients with fluctuating Parkinson's disease (PD) …
innovation of the past 30 years for patients with fluctuating Parkinson's disease (PD) …
[HTML][HTML] Toward electrophysiology-based intelligent adaptive deep brain stimulation for movement disorders
Deep brain stimulation (DBS) represents one of the major clinical breakthroughs in the age
of translational neuroscience. In 1987, Benabid and colleagues demonstrated that high …
of translational neuroscience. In 1987, Benabid and colleagues demonstrated that high …
Deep brain stimulation: a review of the open neural engineering challenges
Objective. Deep brain stimulation (DBS) is an established and valid therapy for a variety of
pathological conditions ranging from motor to cognitive disorders. Still, much of the DBS …
pathological conditions ranging from motor to cognitive disorders. Still, much of the DBS …
Modulation of beta bursts in subthalamic sensorimotor circuits predicts improvement in bradykinesia
No biomarker of Parkinson's disease exists that allows clinicians to adjust chronic therapy,
either medication or deep brain stimulation, with real-time feedback. Consequently …
either medication or deep brain stimulation, with real-time feedback. Consequently …
Globus pallidus internus (GPi) deep brain stimulation for Parkinson's disease: expert review and commentary
Introduction The globus pallidus internus (GPi) region has evolved as a potential target for
deep brain stimulation (DBS) in Parkinson's disease (PD). DBS of the GPi (GPi DBS) is an …
deep brain stimulation (DBS) in Parkinson's disease (PD). DBS of the GPi (GPi DBS) is an …
Embedded adaptive deep brain stimulation for cervical dystonia controlled by motor cortex theta oscillations
Dystonia is a disabling movement disorder characterized by excessive muscle contraction
for which the underlying pathophysiology is incompletely understood and treatment …
for which the underlying pathophysiology is incompletely understood and treatment …
[HTML][HTML] Cortical beta burst dynamics are altered in Parkinson's disease but normalized by deep brain stimulation
Exaggerated subthalamic beta oscillatory activity and increased beta range cortico-
subthalamic synchrony have crystallized as the electrophysiological hallmarks of …
subthalamic synchrony have crystallized as the electrophysiological hallmarks of …
[HTML][HTML] Acute effects of adaptive Deep Brain Stimulation in Parkinson's disease
Abstract Background Beta-based adaptive Deep Brain Stimulation (aDBS) is effective in
Parkinson's disease (PD), when assessed in the immediate post-implantation phase …
Parkinson's disease (PD), when assessed in the immediate post-implantation phase …
Controlling clinical states governed by different temporal dynamics with closed-loop deep brain stimulation: a principled framework
Closed-loop strategies for deep brain stimulation (DBS) are paving the way for improving the
efficacy of existing neuromodulation therapies across neurological disorders. Unlike …
efficacy of existing neuromodulation therapies across neurological disorders. Unlike …