Designing artificial metalloenzymes by tuning of the environment beyond the primary coordination sphere
Metalloenzymes catalyze a variety of reactions using a limited number of natural amino
acids and metallocofactors. Therefore, the environment beyond the primary coordination …
acids and metallocofactors. Therefore, the environment beyond the primary coordination …
Engineering new catalytic activities in enzymes
The efficiency, selectivity and sustainability benefits offered by enzymes are enticing
chemists to consider biocatalytic transformations to complement or even supplant more …
chemists to consider biocatalytic transformations to complement or even supplant more …
Navigating the unnatural reaction space: directed evolution of heme proteins for selective carbene and nitrene transfer
Conspectus Despite the astonishing diversity of naturally occurring biocatalytic processes,
enzymes do not catalyze many of the transformations favored by synthetic chemists. Either …
enzymes do not catalyze many of the transformations favored by synthetic chemists. Either …
Nature's machinery, repurposed: expanding the repertoire of iron-dependent oxygenases
Iron is an especially important redox-active cofactor in biology because of its ability to
mediate reactions with atmospheric O2. Iron-dependent oxygenases exploit this earth …
mediate reactions with atmospheric O2. Iron-dependent oxygenases exploit this earth …
Dual-function enzyme catalysis for enantioselective carbon–nitrogen bond formation
Chiral amines can be made by insertion of a carbene into an N–H bond using two-catalyst
systems that combine a transition metal-based carbene-transfer catalyst and a chiral proton …
systems that combine a transition metal-based carbene-transfer catalyst and a chiral proton …
Iron catalysts with N-ligands for carbene transfer of diazo reagents
C Damiano, P Sonzini, E Gallo - Chemical Society Reviews, 2020 - pubs.rsc.org
Transition-metal-catalyzed carbene transfer reactions, involving diazo compounds and their
precursors, are powerful tools for creating new C–C bonds. Depending on the involved …
precursors, are powerful tools for creating new C–C bonds. Depending on the involved …
Iron: A worthy contender in metal carbene chemistry
VF Batista, DC GA Pinto, AMS Silva - ACS Catalysis, 2020 - ACS Publications
Carbene transfer reactions hold a pivotal role in organic synthesis, allowing the prompt
construction of complex molecules from accessible reagents. Iron complexes emerged as …
construction of complex molecules from accessible reagents. Iron complexes emerged as …
Origin and Control of Chemoselectivity in Cytochrome c Catalyzed Carbene Transfer into Si–H and N–H bonds
A cytochrome c heme protein was recently engineered to catalyze the formation of carbon–
silicon bonds via carbene insertion into Si–H bonds, a reaction that was not previously …
silicon bonds via carbene insertion into Si–H bonds, a reaction that was not previously …
Synthesis of Rhodium Complexes with Chiral Diene Ligands via Diastereoselective Coordination and Their Application in the Asymmetric Insertion of Diazo …
A new method for the synthesis of chiral diene rhodium catalysts is introduced. The readily
available racemic tetrafluorobenzobarrelene complexes [(R2‐TFB) RhCl] 2 were separated …
available racemic tetrafluorobenzobarrelene complexes [(R2‐TFB) RhCl] 2 were separated …
Enzymatic lactone-carbene C–H insertion to build contiguous chiral centers
We report a biocatalytic platform of engineered cytochrome P411 enzymes (P450s with axial
serine ligation) to carry out efficient lactone-carbene insertion into primary and secondary α …
serine ligation) to carry out efficient lactone-carbene insertion into primary and secondary α …